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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. May 7, 2013; 19(17): 2650-2659
Published online May 7, 2013. doi: 10.3748/wjg.v19.i17.2650
Published online May 7, 2013. doi: 10.3748/wjg.v19.i17.2650
Prognostic and survival analysis of 837 Chinese colorectal cancer patients
Ying Yuan, Mo-Dan Li, Han-Guang Hu, Cai-Xia Dong, Jia-Qi Chen, Xiao-Fen Li, Jing-Jing Li, Hong Shen, Department of Medical Oncology, 2nd Hospital of Zhejiang University College of Medicine, Hangzhou 310009, Zhejiang Province, China
Author contributions: Yuan Y directed the study, data acquisition and data analysis, and drafted the manuscript; Li MD co-supervised the field activities and designed the study analysis strategy; Hu HG and Dong CX reviewed and edited the whole manuscript; Chen JQ, Li XF and Li JJ carried out data interpretation; Shen H designed the study, co-supervised the field activities, and revised the manuscript critically for important intellectual content.
Supported by The Grants from National Natural Science Foundation of China, No. 81102013, No. 81101580; Zhejiang Provincial Natural Science Foundation of China, No. R2090353; National High Technology Research and Development Program of China, No. 2012AA02A506
Correspondence to: Dr. Hong Shen, Department of Medical Oncology, 2nd Hospital of Zhejiang University College of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. shenhong0023@gmail.com
Telephone: +86-571-87784795 Fax: +86-571-87767088
Received: October 31, 2012
Revised: February 27, 2013
Accepted: March 6, 2013
Published online: May 7, 2013
Processing time: 187 Days and 13.3 Hours
Revised: February 27, 2013
Accepted: March 6, 2013
Published online: May 7, 2013
Processing time: 187 Days and 13.3 Hours
Core Tip
Core tip: Recent reports and reviews have highlighted the importance of metastatic lymph node and Lymph node ratio (LNR) in predicting prognosis of colorectal cancer (CRC). We found that the histological grade, depth of bowel wall invasion, and number of metastatic lymph nodes were the most important prognostic factor for CRC without consideration of the interaction of the tumor node metastasis staging system. LNR was a powerful factor for estimating the survival of stage III CRC. This paper presents new results on the 5-year overall survival and prognostic factors in Chinese CRC patients.