Original Article
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Apr 28, 2013; 19(16): 2473-2480
Published online Apr 28, 2013. doi: 10.3748/wjg.v19.i16.2473
Overexpression of carbonic anhydrase II and Ki-67 proteins in prognosis of gastrointestinal stromal tumors
Li-Cheng Liu, Wen-Tong Xu, Xin Wu, Po Zhao, Ya-Li Lv, Lin Chen
Li-Cheng Liu, Wen-Tong Xu, Xin Wu, Lin Chen, Department of General Surgery, General Hospital of PLA, Beijing 100853, China
Po Zhao, Ya-Li Lv, Department of Pathology, General Hospital of PLA, Beijing 100853, China
Author contributions: Liu LC performed the majority of experiments, collected data and wrote the manuscript; Xu WT was in charge of this project, and revised the manuscript and provided financial support for this work; Zhao P and Lv YL provided vital reagents and analytical tools; Wu X and Chen L reviewed the manuscript.
Correspondence to: Wen-Tong Xu, MD, Department of General Surgery, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, China. xuwentong@medmail.com.cn
Telephone: +86-10-66938328 Fax: +86-10-66938327
Received: January 13, 2013
Revised: March 7, 2013
Accepted: March 22, 2013
Published online: April 28, 2013
Processing time: 55 Days and 18 Hours
Core Tip

Core tip: Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors with a wide spectrum of clinical behavior. This is the first study showing the prognostic significance of carbonic anhydrase II (CA II) and Ki-67. The 1-, 3- and 5-year survival rates were 90.0%, 82.0% and 72.0%. However, in patients with positive CA II or Ki-67, the survival rates were 92.0%, 83.0% and 77.0% or 83.0%, 66.6% and 53.0%, respectively. Our study indicates that CA II has strong expression in GISTs and prognosis with high CA II expression is better than that with low or no expression, suggesting that CA II is both a diagnostic and prognostic biomarker for GIST.