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World J Gastroenterol. Apr 28, 2013; 19(16): 2449-2455
Published online Apr 28, 2013. doi: 10.3748/wjg.v19.i16.2449
Published online Apr 28, 2013. doi: 10.3748/wjg.v19.i16.2449
Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma
Lydia Giannitrapani, Maurizio Soresi, Daniele Balasus, Anna Licata, Giuseppe Montalto, Unit of Internal Medicine, Biomedical Department of Internal Medicine and Specialties DiBiMIS, University of Palermo, 90127 Palermo, Italy
Author contributions: Giannitrapani L and Soresi M collected and analyzed literature data; Balasus D and Licata A contributed analytic tools; Montalto G supervised the paper and Giannitrapani L wrote the paper.
Correspondence to: Dr. Lydia Giannitrapani, Unit of Internal Medicine, Biomedical Department of Internal Medicine and Specialties, University of Palermo, Via del Vespro 141, 90127 Palermo, Italy. lydia.giannitrapani@unipa.it
Telephone: +39-91-6552916 Fax: +39-91-6552977
Received: December 16, 2012
Revised: March 6, 2013
Accepted: March 22, 2013
Published online: April 28, 2013
Processing time: 153 Days and 11.9 Hours
Revised: March 6, 2013
Accepted: March 22, 2013
Published online: April 28, 2013
Processing time: 153 Days and 11.9 Hours
Core Tip
Core tip: Several studies suggested the possibility of an association between -174 interleukin-6 gene G/C polymorphism and some liver diseases however, the data in the literature are still controversial. This work aims to review the literature data on the role of this polymorphism and its possible biological function in chronic liver diseases and hepatocellular carcinoma.