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World J Gastroenterol. Dec 21, 2012; 18(47): 7040-7047
Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7040
Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7040
Effect of salvianolate on intestinal epithelium tight junction protein zonula occludens protein 1 in cirrhotic rats
Dan-Hong Yang, Department of Infection, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China
Zai-Yuan Ye, Department of Surgery, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China
Yuan-Jun Xie, the Third School of Clinical Medicine, Zhejiang Traditional University, Hangzhou 310053, Zhejiang Province, China
Xu-Jun He, Wen-Juan Xu, Key Laboratory of Gastroenterology and Pathology, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China
Wei-Ming Zhou, Department of Animal Care, Zhejiang Traditional University, Hangzhou 310053, Zhejiang Province, China
Author contributions: Yang DH designed the study, carried out the data interpretation and statistical analysis, and drafted the manuscript; Ye ZY contributed equally to the study conception and design, data interpretation and manuscript preparation; Xie YJ analyzed the tight junction ultrastructural changes using transmission electron microscopy; He XJ provided the vital reagents and performed zonula occludens protein 1 expression analysis using immunocytochemistry; Zhou WM and Xu WJ established the model of cirrhotic rats and completed the hematoxylin and eosin staining for liver histological evaluation.
Supported by Foundation of Chinese Medicine in Zhejiang Province Science and Technology, No. Z0102B002
Correspondence to: Zai-Yuan Ye, MD, Director of Key Laboratory of Gastroenterology and Pathology, Department of Surgery, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China. ydh-11@163.com
Telephone: +86-571-85893602 Fax: +86-571-85131448
Received: June 12, 2012
Revised: September 18, 2012
Accepted: September 22, 2012
Published online: December 21, 2012
Revised: September 18, 2012
Accepted: September 22, 2012
Published online: December 21, 2012
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