Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas

doi:10.3748/wjg.v16.i10.1201

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Mar 14, 2010 (publication date) through Nov 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2010; 16(10): 1201-1208
Published online Mar 14, 2010. doi: 10.3748/wjg.v16.i10.1201

Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas

Xian-Zi Wen, Yoshimitsu Akiyama, Kai-Feng Pan, Zhao-Jun Liu, Zhe-Ming Lu, Jing Zhou, Lian-Kun Gu, Cai-Xuan Dong, Bu-Dong Zhu, Jia-Fu Ji, Wei-Cheng You, Da-Jun Deng

Xian-Zi Wen, Zhao-Jun Liu, Zhe-Ming Lu, Jing Zhou, Lian-Kun Gu, Da-Jun Deng, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Etiology, Peking University School of Oncology and Beijing Cancer Hospital & Institute, Fucheng Road No. 52, Haidian District, Beijing 100142, China

Yoshimitsu Akiyama, Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

Kai-Feng Pan, Cai-Xuan Dong, Wei-Cheng You, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Epidemiology, Peking University School of Oncology and Beijing Cancer Hospital, Fucheng Road No. 52, Haidian District, Beijing 100142, China

Bu-Dong Zhu, Department of Internal Medicine, Peking University School of Oncology and Beijing Cancer Hospital, Fucheng Road No. 52, Haidian District, Beijing 100142, China

Jia-Fu Ji, Department of Surgery, Peking University School of Oncology and Beijing Cancer Hospital, Fucheng Road No. 52, Haidian District, Beijing 100142, China

Author contributions: Wen XZ participated in the study design and conducted methylation specific polymerase chain reaction, clone sequencing, immunohistochemical staining assays and wrote the manuscript; Akiyama Y participated in the study design; Pan KF, Dong CX and You WC conducted the ¹³C-breath test and collected gastric dysplasia samples from subjects in Linqu County; Liu ZJ quantified GATA-4 methylation by denatured high performance liquid chromatography; Lu ZM analyzed Helicobacter pylori by polymerase chain reaction; Zhou J extracted genetic DNA from all tissue samples; Gu LK prepared gastric cancer tissue sections; Zhu BD collected the gastric biopsies from the outpatients; Ji JF collected the paired sporadic gastric carcinomas at Beijing Cancer Hospital; Deng DJ designed and coordinated the study, analyzed the data, and revised the manuscript.

Supported by (in part) National High Technology R&D Program, No. 2006AA02A402 and No. 2010CB529300-G, and NSFC Grant, No. 30921140311 to Deng DJ

Correspondence to: Da-Jun Deng, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Etiology, Peking University School of Oncology and Beijing Cancer Hospital & Institute, Fucheng Road No. 52, Haidian District, Beijing 100142, China. dengdajun@bjmu.edu.cn

Telephone: +86-10-88196752 Fax: +86-10-88122437

Received: November 25, 2009
Revised: December 10, 2009
Accepted: December 17, 2009
Published online: March 14, 2010

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