Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2024; 30(8): 855-862
Published online Feb 28, 2024. doi: 10.3748/wjg.v30.i8.855
Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in Helicobacter pylori-infected patients
Li-Hui Wang, Bin-Bin Su, Sheng-Shu Wang, Guan-Chao Sun, Kun-Ming Lv, Yi Li, Hui Shi, Qian-Qian Chen
Li-Hui Wang, Guan-Chao Sun, Kun-Ming Lv, Medical College, Chinese PLA General Hospital, Beijing 100853, China
Li-Hui Wang, Bin-Bin Su, Guan-Chao Sun, Kun-Ming Lv, Hui Shi, Department of Gastroenterology, Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Sheng-Shu Wang, Institute of Geriatrics, The 2nd Medical Center, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Yi Li, Qian-Qian Chen, Department of Gastroenterology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Co-first authors: Li-Hui Wang and Bin-Bin Su.
Co-corresponding authors: Qian-Qian Chen and Hui Shi.
Author contributions: Su BB, Lv KM, Li Y, Shi H, and Chen QQ are gastroenterologists; Wang SS is a statistician; Wang LH and Sun GC are master degree candidates; Shi H and Chen QQ performed the disease diagnosis; Wang LH, Su BB, Shi H, and Chen QQ designed the research study; Su BB and Wang SS performed the primary literature and data extraction; Wang LH, Su BB, and Wang SS analyzed the data and wrote the manuscript; Sun GC, Lv KM, Li Y, Shi H, and Chen QQ revised the manuscript for important intellectual content; and all authors read and approved the final version.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the PLA General Hospital (Ethics audits No. S2022-414-01).
Informed consent statement: Patients were not required to provide informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to test by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qian-Qian Chen, MD, Associate Chief Physician, Associate Professor, Department of Gastroenterology, First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. qian_qian_chen@163.com
Received: December 8, 2023
Peer-review started: December 8, 2023
First decision: December 27, 2023
Revised: January 4, 2024
Accepted: January 29, 2024
Article in press: January 29, 2024
Published online: February 28, 2024
ARTICLE HIGHLIGHTS
Research background

Reflux esophagitis has an increasing prevalence and complex and diverse symptoms. Identifying its risk factors is crucial to understanding the etiology, prevention, and management of the disease.

Research motivation

The occurrence of reflux esophagitis may be associated with food reactions, Helicobacter pylori (H. pylori) infection, and metabolic syndromes.

Research objectives

To investigate the risk factors for reflux esophagitis and analyze the effects of IgG-mediated food intolerance, H. pylori infection, and metabolic syndrome on reflux esophagitis.

Research methods

This retrospective study analyzed endoscopic images of outpatients attending the Second Medical Center of PLA General Hospital between 2017 and 2021, classified them into non-RE and RE groups, and further explored the differences in IgG-mediated food intolerance, H. pylori infection, and metabolic syndrome of the different groups.

Research results

In 7954 outpatients, the prevalence of reflux esophagitis was 20.84%.

Research conclusions

Patients with IgG-mediated food intolerance and metabolic syndrome are at higher risk of developing reflux esophagitis, while those with H. pylori infection are at lower risk. IgG-mediated FI reduces the risk of RE in patients with H. pylori infection, while metabolic syndrome increases the risk of RE in these patients.

Research perspectives

In the management of RE, preventing the induction of IgG-mediated FI and optimal diagnosis and treatment of metabolic syndrome may reduce the occurrence of RE.