Published online Dec 21, 2023. doi: 10.3748/wjg.v29.i47.6138
Peer-review started: August 4, 2023
First decision: October 25, 2023
Revised: November 7, 2023
Accepted: December 8, 2023
Article in press: December 8, 2023
Published online: December 21, 2023
Endoscopic resection of superficial esophageal squamous cell carcinoma (ESCC) is limited to lesions that have no or low risk of lymph node metastasis (LNM). Patients with a high risk of LNM always need further treatment after endoscopic resection.
Accurately assessing the LNM risk is critical for additional treatment choices for superficial ESCC patients who underwent endoscopic resection.
This study aimed to analyze the risk factors for LNM and develop a LNM predictive nomogram for superficial ESCC patients.
Clinical and pathological data from superficial ESCC patients underwent esopha
A total of 474 superficial ESCC patients were enrolled. The prevalence of LNM was 3.29% for intramucosal cancer and increased to 26.40% for submucosal cancer. A nomogram incorporating six variables, including tumor size, invasion depth, tumor differentiation, tumor budding, tumor infiltrative growth pattern, and lymphovascular invasion, was successfully developed.
We developed a useful nomogram model to predict LNM risk for superficial ESCC patients, which will facilitate additional treatment decisions for patients who underwent endoscopic resection.
The nomogram model is a simple and useful tool to facilitate the prediction of LNM risk for superficial ESCC patients.