Published online Nov 21, 2023. doi: 10.3748/wjg.v29.i43.5848
Peer-review started: August 30, 2023
First decision: October 8, 2023
Revised: October 21, 2023
Accepted: November 7, 2023
Article in press: November 7, 2023
Published online: November 21, 2023
Processing time: 81 Days and 14.4 Hours
Gastric ulcer (GU) is a common digestive system disease. In addition to western medicine treatment, more and more Chinese herbs have become the first choice for alternative treatment due to their long history of use, high efficacy, low side effects and low price.
Although the herbal medicine Atractylodes japonica Koidz. ex Kitam. (A. japonica) has an obvious therapeutic effect on GU, there are few relevant mechanism studies at present.
The object of this study is to investigate the protective effects of A. japonica on acetic acid-induced GU rats.
We used ultra performance liquid chromatography tandem mass spectrometry, hematoxylin-eosin stain, enzyme-linked immunosorbent assay, real-time reverse transcription polymerase chain reaction and acetic acid-induced GU model to evaluate the therapeutic effect of A. japonica.
48 chemical constituents of A. japonica were identified, the herb significantly improved the pathological damage of gastric tissues, increased the expression levels of anti-inflammatory factors, decreased the expression levels of proinflammatory factors, restored the levels of factors about ulcer healing and energy metabolism. and identified 10 potential differential metabolites and enriched 7 related metabolic pathways of metabolomic analysis.
The therapeutic effect of A. japonica on GU rats is closely related to anti-inflammation and repair of gastric injury, and is regulated and treated through a combination of multiple pathways.
These findings contribute to the understanding of the potential mechanism of A. japonica to improve acetic acid-induced GU, and will provide great importance for the development and clinical application of A. japonica.