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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Mucosal patterns change after Helicobacter pylori eradication: Evaluation using blue laser imaging in patients with atrophic gastritis
Yoshiyuki Nishikawa, Yoshio Ikeda, Hidehiro Murakami, Shin-Ichiro Hori, Megumi Yoshimatsu, Naoki Nishikawa
Yoshiyuki Nishikawa, Department of Gastroenterology, Nishikawa Gastrointestinal Clinic, Matsuyama 790-0878, Ehime, Japan
Yoshio Ikeda, Endoscopy Center, Ehime University Hospital, Toon 791-0295, Ehime, Japan
Hidehiro Murakami, Department of Internal Medicine, Saiseikai Matsuyama Hospital, Matsuyama 791-8026, Ehime, Japan
Shin-Ichiro Hori, Department of Gastroenterology, Himeji Red Cross Hospital, Himeji 670-8540, Hyogo, Japan
Megumi Yoshimatsu, Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matsuyama 791-0280, Ehime, Japan
Naoki Nishikawa, Department of Gastroenterology, Matsuyama Shimin Hospital, Matsuyama 790-0067, Ehime, Japan
Author contributions: Nishikawa Y conceived and designed the study; Nishikawa Y, Ikeda Y, Murakami H, Hori S, and Yoshimatsu M analyzed and interpreted the data; Nishikawa Y and Nishikawa N drafted the manuscript; Nishikawa Y, Ikeda Y, Murakami H, Hori S, Yoshimatsu M, and Nishikawa N critically revised the manuscript for important intellectual content; Nishikawa Y gave final approval of the manuscript; all authors approved the final version of the article to be published.
Institutional review board statement: This study was approved by the Ethics Committee of Ehime University Hospital (No. 1605010; August 22, 2016).
Informed consent statement: This study was conducted retrospectively from data obtained for clinical purposes. The study was approved by the institutional review board at the Ethics Committee of Ehime University Hospital. Prior to receiving an endoscopic examination, all patients agreed that the data obtained in this study might be published in academic papers.
Conflict-of-interest statement: None of the authors have any financial relationships to disclose with relevance to this article.
Data sharing statement: Data presented in this study is available on request from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Yoshiyuki Nishikawa, MD, PhD, Director, Department of Gastro-enterology, Nishikawa Gastrointestinal Clinic, 2-72 Katsuyama-cho, Matsuyama 790-0878, Ehime, Japan. yonishik@ehime.med.or.jp
Received: February 8, 2023
Peer-review started: February 8, 2023
First decision: February 16, 2023
Revised: March 3, 2023
Accepted: April 7, 2023
Article in press: April 7, 2023
Published online: May 7, 2023
ARTICLE HIGHLIGHTS
Research background
Determination of the presence or absence of Helicobacter pylori (H. pylori) infection is important in the diagnosis of atrophic gastritis. Various studies have been conducted to distinguish these two conditions.
Research motivation
In our previous study, we reported that H. pylori eradication may lead to the disappearance of the spotty pattern and the appearance of the cracked pattern.
Research objectives
To further substantiate and comprehensively investigate mucosal pattern changes after H. pylori eradication in a larger number of patients.
Research methods
Among the patients with atrophic gastritis in whom H. pylori positivity was confirmed, we investigated 101 patients who underwent both H. pylori eradication and follow-up endoscopy and evaluated the change of patterns before and after eradication.
Research results
The spotty pattern tended to disappear or decrease, and the cracked pattern tended to appear or increase after H. pylori eradication, while the mottled pattern exhibited no specific tendency.
Research conclusions
The spotty pattern likely changes to the cracked pattern after H. pylori eradication.
Research perspectives
In future studies, it will be necessary to examine the morphological and histological changes of each mucosal pattern, compare these pattern changes with the Kyoto classification, examine the relationship with other classifications of atrophic gastritis, and clarify the meaning of the mucosal pattern changes.
