Published online Mar 21, 2023. doi: 10.3748/wjg.v29.i11.1745
Peer-review started: October 24, 2022
First decision: November 2, 2022
Revised: November 7, 2022
Accepted: March 6, 2023
Article in press: March 6, 2023
Published online: March 21, 2023
Human immunodeficiency virus (HIV)-positive patients coinfected with hepatitis B virus (HBV) are eligible for liver transplantation (LT) in Africa and Southeast Asia, particularly China. However, the outcome of HIV-HBV coinfected patients referred for ABO-incompatible LT (ABOi-LT) is unknown.
There have been no reports about the intermediate-term outcome of ABOi-LT in HIV-HBV coinfected recipients.
We sought to clarify the outcome of ABOi-LT for HIV-HBV coinfected patients with end-stage liver disease (ESLD).
We report on two Chinese HIV-HBV coinfected patients with ESLD who underwent A to O brain-dead donor LT and reviewed the literature on HIV-HBV coinfected patients treated with ABO-compatible LT. Data of the pre- and post-transplantation were collected, including HIV viral load, CD4(+) T cell count, induction therapy methods, the immunosuppressive regimen and the clinical materials.
After follow-up for 36-42 mo, both patients survived with undetectable HIV viral load, CD4(+) T cell counts greater than 150 cells/μL, no HBV recurrence, and stable liver function. Liver biopsy showed no evidence of acute cellular rejection.
This is the first study of ABOi-LT in HIV-HBV recipients with good intermediate-term outcomes, which suggests that ABOi-LT may be feasible and safe for HIV-HBV coinfected patients with ESLD.
Due to the relatively small number of cases in the study, follow-up studies with large samples are still required.