Published online Jan 21, 2022. doi: 10.3748/wjg.v28.i3.365
Peer-review started: November 26, 2021
First decision: December 12, 2021
Revised: December 14, 2021
Accepted: January 11, 2022
Article in press: January 11, 2022
Published online: January 21, 2022
The gastric microbiome through the histological stages of gastric tumorigenesis remains poorly understood, especially for the Helicobacter pylori-negative gastric cancer (HPNGC).
To get a better knowledge of gastric microbiota and to identify microbial indicators at different histological stages of gastric tumorigenesis.
To identify distinct taxa in precancerous lesions and describe microbial profiles of gastric mucosa and juice for HPNGC carcinogenesis.
We designed a clinical cohort study and utilized the 16S rRNA gene sequencing analysis.
Our study showed a change in the gastric microbial community structure along the precancerous lesions in the Helicobacter pylori-negative stages. Patients with intestinal metaplasia and dysplasia had similar gastric mucosa microbiota profiles, and their potential to be indicators for prognosis. Our findings revealed that the bacterial community of gastric juice differed from that of the gastric mucosa, and that HPNGC and its precancerous lesions have distinct bacterial taxa.
Using the gastric microbiota profile, we were able to identify possible taxonomic biomarkers for HPNGC and its precancerous phases, as well as help predict prognoses for intestinal metaplasia and dysplasia.
Our research revealed the core pathogenic bacteria in Helicobacter pylori-negative precancerous lesions, allowing for further investigation of the pathogenic process.