Published online Jul 28, 2022. doi: 10.3748/wjg.v28.i28.3695
Peer-review started: April 6, 2022
First decision: May 29, 2022
Revised: May 30, 2022
Accepted: June 30, 2022
Article in press: June 30, 2022
Published online: July 28, 2022
Intrahepatic cholangiocarcinoma (ICC) is one of the most aggressive malignancies. However, because of its scarcity few population-based studies have explored its epidemiology. In Taiwan, we have a national cancer registry database, which can be used to evaluate the epidemiology of ICC.
To discover the secular incidence trends and associated risk factors of ICC in Taiwan.
To observe secular trends in ICC incidence according to age, sex, and risk factors in Taiwan.
In this population-based study, we used the national Taiwan Cancer Registry database. Relative percent change in incidence rates were used to describe secular trends in incidence rates and sex ratios of ICC in Taiwan.
The age-standardized ICC incidence rate among males increased from 1.51 per 100000 in 1993-1997 to 4.07 per 100000 in 2013-2017 and among females from 1.73 per 100000 to 2.95 per 100000. ICC incidence rates in females tended to plateau after 2008-2012. For males, the incidence of ICC increased as age increased. In the long-term incidence trend of ICC in females, the incidence of the four age groups of 40-44, 45-49, 50-54, and 55-59 years remained stable in different years, the incidence of the 60-64 age group had a peak in 2003-2007, and the peak incidence in the 65-69 and 70-74 age groups occurred in 2008-2012.
An increased incidence of ICC has occurred in Taiwan over the past two decades. The increased sex ratios has progressively shifted toward younger people.
Further long-term cohort studies are needed to investigate the relationship between ICC and its risk factors.