High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy
Ulrike Bauer, Sabine Gerum, Falk Roeder, Stefan Münch, Stephanie E Combs, Alexander B Philipp, Enrico N De Toni, Martha M Kirstein, Arndt Vogel, Carolin Mogler, Bernhard Haller, Jens Neumann, Rickmer F Braren, Marcus R Makowski, Philipp Paprottka, Markus Guba, Fabian Geisler, Roland M Schmid, Andreas Umgelter, Ursula Ehmer
Ulrike Bauer, Fabian Geisler, Roland M Schmid, Andreas Umgelter, Ursula Ehmer, Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany
Sabine Gerum, Falk Roeder, Department of Radiotherapy and Radiation Oncology, University of Salzburg, Salzburg 5020, Austria
Sabine Gerum, Falk Roeder, Department of Radiation Oncology, University Hospital of Munich, Campus Großhadern, LMU Munich, Munich 81377, Germany
Stefan Münch, Stephanie E Combs, Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany
Alexander B Philipp, Enrico N De Toni, Department of Medicine II, Liver Centre, University Hospital, LMU Munich, Munich 81377, Germany
Martha M Kirstein, Arndt Vogel, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany
Carolin Mogler, Institute of Pathology, Technical University of Munich, Munich 81675, Germany
Bernhard Haller, Institute of Medical Informatics, Statistics and Epidemiology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany
Jens Neumann, Institute of Pathology, Faculty of Medicine, University Hospital of Munich, Munich 81377, Germany
Rickmer F Braren, Marcus R Makowski, Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany
Philipp Paprottka, Institute of Diagnostic and Interventional Radiology, Section for Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany
Markus Guba, Department of General-, Visceral-, Vascular- and Transplant-Surgery, University hospital of Munich, Campus Großhadern, LMU Munich, Munich 81377, Germany
Andreas Umgelter, Emergency Department, Vivantes hospital group, Humboldt hospital, Berlin 13509, Germany
Author contributions: Bauer U, Gerum S, Roeder F, Münch S, Combs SE, Philipp AB, De Toni EN, Kirstein MM, Vogel A, Paprottka P, Guba M, Geisler F, Schmid RM, Umgelter A, and Ehmer U analyzed data; Bauer U, Gerum S, Münch S, Mogler C, Neumann J, Braren RF, Makowski MR, and Ehmer U designed and reviewed figures; Combs SE, De Toni EN, Vogel A, Haller B, Braren RF, Makowski MR, Geisler F, Schmid RM, and Umgelter A critically revised the manuscript; Bauer U, Gerum S, Schmid RM, Umgelter A and Ehmer U concepted the study; Bauer U and Ehmer U wrote the manuscript.
Institutional review board statement: This study was reviewed and approved by the local Ethics Committee of each participating center.
Informed consent statement: We performed a retrospective analysis and all data were completely anonymized for analysis and storage. In addition, there was no risk for the subjects as our study was a retrospective analysis of patients treated with standard of care procedures. According to local ethics committees there is no informed consent required given the retrospective study design, anonymous data analysis, and lack of any risks for the subjects in this study.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available as they could compromise the privacy of research participants.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Ursula Ehmer, MD, PhD, Doctor, Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 21, Munich 81675, Germany.
ursula.ehmer@tum.de
Received: February 5, 2021
Peer-review started: February 5, 2021
First decision: March 6, 2021
Revised: March 20, 2021
Accepted: May 19, 2021
Article in press: May 19, 2021
Published online: June 28, 2021
Processing time: 139 Days and 21.6 Hours
