Wen Y, Chen YW, Meng AH, Zhao M, Fang SH, Ma YQ. Idiopathic mesenteric phlebosclerosis associated with long-term oral intake of geniposide. World J Gastroenterol 2021; 27(22): 3097-3108 [PMID: 34168411 DOI: 10.3748/wjg.v27.i22.3097]
Corresponding Author of This Article
Yan-Qing Ma, MD, Doctor, Department of Radiology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou 310014, Zhejiang Province, China. 704180026@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 14, 2021; 27(22): 3097-3108 Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.3097
Idiopathic mesenteric phlebosclerosis associated with long-term oral intake of geniposide
Yang Wen, You-Wei Chen, Ai-Hong Meng, Ming Zhao, Song-Hua Fang, Yan-Qing Ma
Yang Wen, Song-Hua Fang, Yan-Qing Ma, Department of Radiology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China
You-Wei Chen, Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China
Ai-Hong Meng, Department of Gastroenterology, Hangzhou Yuhang District Hospital of Traditional Chinese Medicine, Hangzhou 311100, Zhejiang Province, China
Ming Zhao, Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China
Author contributions: Wen Y, Chen YW and Meng AH conceptualized the study and contributed to data analysis and interpretation and manuscript preparation and revision; Zhao M provided writing assistance and proofread the article; Fang SH was involved in data interpretation; Chen YW, Zhao M, Fang SH and Ma YQ contributed to the discussion regarding the manuscript.
Supported bythe Fund of Medical and Health Research Projects of Health Commission of Zhejiang Province, No. 2018KY247 and No. 2019KY035.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board at Zhejiang Provincial People's Hospital, which waived informed consent.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent. Patient confidentiality was protected.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Qing Ma, MD, Doctor, Department of Radiology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou 310014, Zhejiang Province, China. 704180026@qq.com
Received: February 17, 2021 Peer-review started: February 17, 2021 First decision: March 28, 2021 Revised: March 30, 2021 Accepted: April 20, 2021 Article in press: April 20, 2021 Published online: June 14, 2021 Processing time: 111 Days and 0.3 Hours
ARTICLE HIGHLIGHTS
Research background
Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease, and its etiology and risk factors remain uncertain.
Research motivation
In terms of IMP etiology, the association with a region-specific lifestyle has been a concern. IMP is believed to be linked to chronic and frequent ingestion of biochemicals and toxins.
Research objectives
The objective was to explore the possible relationship between Chinese herbal liquid containing geniposide and IMP and to identify some clinical factors that may lead to disease progression.
Research methods
The disease computed tomography (CT) score was calculated from the distribution of mesenteric vein calcification and colon wall thickening on CT images. The drinking index of medicinal liquor was calculated from the daily intake and drinking years. The correlation between the drinking index and the disease CT score was analyzed by Spearman’s correlation analysis. Comparison of the herbal ingredients included in the liquid prescriptions, allowed identification of possibly toxic agents as a pathogenic factor.
Research results
Geniposide was the only Chinese medicine in common with previous studies. Spearman’s correlation analysis revealed that the median CT disease score was positively correlated with the median drinking index (r = 0.842, P < 0.05).
Research conclusions
Geniposide is most likely involved in the pathology of IMP, and its effect is time- and dose-dependent. Chronic nephritis, malignant tumors, diabetes mellitus, and other clinical symptoms may be risk factors for IMP.
Research perspectives
The number of cases in our retrospective study was relatively small, and the pathogenesis of IMP needs to be determined by further study with a larger data set.
