Saghir SM, Mashiana HS, Mohan BP, Dhindsa BS, Dhaliwal A, Chandan S, Bhogal N, Bhat I, Singh S, Adler DG. Efficacy of pancreatoscopy for pancreatic duct stones: A systematic review and meta-analysis. World J Gastroenterol 2020; 26(34): 5207-5219 [PMID: 32982119 DOI: 10.3748/wjg.v26.i34.5207]
Corresponding Author of This Article
Douglas G Adler, FACG, FASGE, MD, Professor, Division of Gastroenterology and Hepatology, University of Utah Health, 50 N Medical Dr., Salt Lake City, UT 84132, United States. douglas.adler@hsc.utah.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 14, 2020; 26(34): 5207-5219 Published online Sep 14, 2020. doi: 10.3748/wjg.v26.i34.5207
Efficacy of pancreatoscopy for pancreatic duct stones: A systematic review and meta-analysis
Syed M Saghir, Harmeet S Mashiana, Babu P Mohan, Banreet S Dhindsa, Amaninder Dhaliwal, Saurabh Chandan, Neil Bhogal, Ishfaq Bhat, Shailender Singh, Douglas G Adler
Syed M Saghir, Banreet S Dhindsa, Department of Internal Medicine, University of Nevada Las Vegas School of Medicine, Las Vegas, NV 89102, United States
Harmeet S Mashiana, Amaninder Dhaliwal, Saurabh Chandan, Neil Bhogal, Ishfaq Bhat, Shailender Singh, Division of Gastroenterology and Hepatology, University of Nebraska School of Medicine, Omaha, NE 68198-2000, United States
Babu P Mohan, Douglas G Adler, Division of Gastroenterology and Hepatology, University of Utah Health, Salt Lake City, UT 84132, United States
Author contributions: Saghir SM, Mashiana HS and Mohan BP contributed to analysis and interpretation of data; Saghir SM and Mashiana HS contributed to drafting the article; Mashiana HS, Dhindsa BS, Dhaliwal A and Bhogal N contributed to acquisition of data; Chandan S, Bhat I and Adler DG contributed to critical revision; Mashiana HS, Singh S and Adler DG contributed to final approval.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Douglas G Adler, FACG, FASGE, MD, Professor, Division of Gastroenterology and Hepatology, University of Utah Health, 50 N Medical Dr., Salt Lake City, UT 84132, United States. douglas.adler@hsc.utah.edu
Received: May 28, 2020 Peer-review started: May 28, 2020 First decision: June 12, 2020 Revised: June 29, 2020 Accepted: August 21, 2020 Article in press: August 21, 2020 Published online: September 14, 2020 Processing time: 103 Days and 14.5 Hours
ARTICLE HIGHLIGHTS
Research background
Painful chronic calcifying pancreatitis management involves pancreatic enzyme replacement therapy, extracorporeal shock wave lithotripsy (ESWL) with or without endoscopic retrograde cholangiopancreatography (ERCP), ERCP with pancreatic sphincterotomy and either balloon or basket retrieval with stent placement, peroral pancreatoscopy (POP) and/or surgery. POP utilizes two different methods for pancreatic stone lithotripsy, which are electrohydraulic lithotripsy (EHL) or laser lithotripsy (LL).
Research motivation
There are limited data regarding the safety and efficacy of POP for symptomatic pancreatic calculi.
Research objectives
We aimed to assess the safety and efficacy of both POP techniques in regard to stone fragmentation. Primary outcomes assessed involved technical and clinical success of POP. Secondary outcomes included technical and clinical success for EHL and LL, and adverse events (AE) for POP, EHL and LL.
Research methods
We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed, EMBASE, Cochrane, Google Scholar and Web of Science databases. Statistical analysis was conducted via comprehensive meta-analysis software.
Research results
POP-guided lithotripsy was successful in patients who had failed in the first-line therapy. On indirect comparative analysis, LL was found to have higher technical and clinical success than EHL. POP AE was comparable to ESWL. The AE for EHL and LL was similar on indirect comparison. PEP was the most common AE and was comparable to ESWL.
Research conclusions
POP-guided lithotripsy is a viable option for management of patients with chronic pancreatitis and symptomatic PD stones. We found LL technique to have a higher technical and clinical success rate with comparable AE rates.
Research perspectives
Further randomized controlled trials are needed for head to head comparison of the two techniques and evaluate if POP can be a potential first line therapy in these cases.
