Liver structural transformation after partial hepatectomy and repeated partial hepatectomy in rats: A renewed view on liver regeneration
Keti Tsomaia, Leila Patarashvili, Nino Karumidze, Irakli Bebiashvili, Elza Azmaipharashvili, Irina Modebadze, Diana Dzidziguri, Marom Sareli, Sergey Gusev, Dimitri Kordzaia
Keti Tsomaia, Leila Patarashvili, Nino Karumidze, Irakli Bebiashvili, Elza Azmaipharashvili, Dimitri Kordzaia, Faculty of Medicine, Ivane Javakhishvili Tbilisi State University, Tbilisi 0159, Georgia
Irina Modebadze, Diana Dzidziguri, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, Georgia
Marom Sareli, Department of Surgical Oncology (Surgery C), Chaim Sheba Medical Center at HaShomer, Tel Aviv 52621, Israel
Sergey Gusev, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russia
Dimitri Kordzaia, Clinical Anatomy and Operative Surgery, Ivane Javakhishvili Tbilisi State University, Tbilisi 0159, Georgia
Author contributions: Tsomaia K and Patarashvili L were responsible for planing experiments, the preparation and evaluation of histological slides, for mor-phometrical, literature search, in data interpretation and manuscript drafting; Karumidze N and Modebadze I were responsible for determination of the DNA concentration of the hepatocytes; Bebiashvili I and Azmaipharashvili E contributed in experiments, in literature search and review and in analysis of the results. Dzidziguri D and Sareli M contributed in planning the experiments and research methodology, in data analysis, manuscript drafting and revision; Gusev S performed SEM investigation, evaluation, description, data analysis, editing and revision of the manuscript; Kordzaia D performed the conceptualization of research, project administration, supervision of experiments and investigation of SEM. Control preparation of the last version of the manuscript; all authors reviewed and approved the final version to be published.
Supported by the Shota Rustaveli National Science Foundation of Georgia, No. DP2016_22 [New Interfaculty Interdisciplinary Structured Doctoral Programme “Translational Biomedicine” (Direction – “ Hepatology” )].
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board (the Ethical Committee) of Aleksandre Natishvili Institute of Morphology, Tbilisi State University.
Institutional animal care and use committee statement: The experimental study was reviewed by bioethical committee of Aleksandre Natishvili Institute of Morphology, Tbilisi State University and approved that this study fully corresponds with EU Directive 2010/63/EU “on the protection of animals used for scientific purposes”.
Conflict-of-interest statement: The authors declare that they have no competing interests. The authors do not have any commercial or collaborative relationships that could be constructed as biased or inappropriate.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared according to these guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Dimitri Kordzaia, DSc, MD, PhD, Dean, Professor, Clinical Anatomy and Operative Surgery, Ivane Javakhishvili Tbilisi State University, Beliashvili str. 78, Tbilisi 0159, Georgia.
dimitri.kordzaia@tsu.ge
Received: February 27, 2020
Peer-review started: February 27, 2020
First decision: April 30, 2020
Revised: May 12, 2020
Accepted: June 23, 2020
Article in press: June 23, 2020
Published online: July 21, 2020
Processing time: 144 Days and 22.4 Hours
