Published online Jan 7, 2020. doi: 10.3748/wjg.v26.i1.55
Peer-review started: November 11, 2019
First decision: November 22, 2019
Revised: November 29, 2019
Accepted: December 14, 2019
Article in press: December 14, 2019
Published online: January 7, 2020
Astragalus polysaccharides (APS) are bioactive components extracted from the radix of Astragalus membranaceus, a commonly used herbal compound in traditional Chinese medicine.
APS was reported to have anti-inflammatory, anti-oxidative, anti-tumor, and anti-diabetic properties.
To evaluate the therapeutic effect of APS and its potential mechanisms in a ulcerative colitis (UC) rat model induced by colon mucosal tissue sensitization combined with trinitro-benzene-sulfonic acid-ethanol.
First, we used two groups of Wistar rats: UC models and controls. Then, 105 UC model rats were randomly divided to five groups: Model group (n = 25), salazopyrine control group (n = 25), APS treatment group (n = 15), matrine treatment group (n = 15), and monomer mixture group (n = 25).
The inflammatory response and oxidative stress injury was relieved in colitis observed in APS combined with matrine-treated mice.
APS combined with matrine may represent a potential therapeutic approach for treating inflammatory bowel disease.
Drug research can provide a valuable resource to help clinicians make strategic treatment choices that will ultimately benefit patients at many levels.