Huang HC, Bian J, Bai Y, Lu X, Xu YY, Sang XT, Zhao HT. Complete or partial split in associating liver partition and portal vein ligation for staged hepatectomy: A systematic review and meta-analysis. World J Gastroenterol 2019; 25(39): 6016-6024 [PMID: 31660037 DOI: 10.3748/wjg.v25.i39.6016]
Corresponding Author of This Article
Hai-Tao Zhao, MD, Professor, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. zhaoht@pumch.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Systematic Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 21, 2019; 25(39): 6016-6024 Published online Oct 21, 2019. doi: 10.3748/wjg.v25.i39.6016
Complete or partial split in associating liver partition and portal vein ligation for staged hepatectomy: A systematic review and meta-analysis
Han-Chun Huang, Jin Bian, Yi Bai, Xin Lu, Yi-Yao Xu, Xin-Ting Sang, Hai-Tao Zhao
Han-Chun Huang, Jin Bian, Yi Bai, Xin Lu, Yi-Yao Xu, Xin-Ting Sang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Author contributions: Huang HC analyzed data, wrote the paper; Bian J performed research; Bai Y contributed analytic tools; Lu X performed research; Xu YY performed research; Sang XT performed research; Zhao HT designed research.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hai-Tao Zhao, MD, Professor, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. zhaoht@pumch.cn
Telephone: +86-10-69156042 Fax: +86-10-69156043
Received: August 24, 2019 Peer-review started: August 24, 2019 First decision: September 10, 2019 Revised: September 17, 2019 Accepted: September 27, 2019 Article in press: September 27, 2019 Published online: October 21, 2019
ARTICLE HIGHLIGHTS
Research background
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been adopted by liver surgeons. However, ALPPS with a partial split has been proposed recent years. Conflicting results have been reported between the ALPPS and partial split of the liver parenchyma in ALPPS (p-ALPPS). This systematic review and meta-analysis evaluated the difference in the future liver remnant (FLR) hypertrophy rate, postoperative morbidity and mortality rates between the ALPPS and p-ALPPS.
Research motivation
The FLR hypertrophy rate and safety between ALPPS and p-ALPPS are controversial.
Research objectives
To compare the currently reported results between ALPPS and p-ALPPS to confirm which is better for patients.
Research methods
We systematically reviewed literatures on the ALPPS and p-ALPPS, and included relevant studies for meta-analysis.
Research results
The total effects indicated no difference in the FLR hypertrophy rate or perioperative morbidity and mortality rates between the ALPPS and p-ALPPS groups. However, p-ALPPS is safer than ALPPS in patients without cirrhosis and exhibits the same rate of FLR hypertrophy.
Research conclusions
In non-cirrhotic patients, p-ALPPS resulted in the same FLR hypertrophy rate compared with the ALPPS, and is safer than ALPPS.
Research perspectives
More studies to compare ALPPS with p-ALPPS in cirrhosis patients should be carried out.
