Retrospective Cohort Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2019; 25(37): 5619-5629
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5619
Accuracy of an administrative database for pancreatic cancer by international classification of disease 10th codes: A retrospective large-cohort study
Young-Jae Hwang, Seon Mee Park, Soomin Ahn, Jong-Chan Lee, Young Soo Park, Nayoung Kim
Young-Jae Hwang, Jong-Chan Lee, Young Soo Park, Nayoung Kim, Departments of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam 13620, South Korea
Seon Mee Park, Department of Internal Medicine, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju 28644, South Korea
Soomin Ahn, Departments of Pathology, Seoul National University Bundang Hospital, Seoungnam 13620, South Korea
Nayoung Kim, Department of Internal Medicine and Institute of Liver Research and Tumor Microenvironment Global Core Research Center, Seoul National University College of Medicine, Seoul 08826, South Korea
Author contributions: Hwang YJ collected data, analyzed data and drafted the article; Park SM advised design of the protocol and edited the manuscript; Ahn S performed the pathologic diagnosis; Lee JC advised the protocol and revised the manuscript; Park YS and Kim N designed the protocol, and edited the manuscript; All authors have read and approved the final draft of this paper.
Supported by the National Research Foundation of Korea, No. 2011-0030001.
Institutional review board statement: This study was approved by the institutional review board of the Ethics Committee of Seoul National University Bundang Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because our study was done retrospectively. Data for study were obtained after each patient agreed to treatment.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: To gain access to data, data requestors will need to sign a data access agreement. Proposals should be directed to the Ethics Committee of Seoul National University Bundang Hospital.
STROBE statement: The guidelines of the STROBE statement have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Nayoung Kim, MD, PhD, Professor, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Seongnam 13620, South Korea. nakim49@snu.ac.kr
Telephone: +82-31-7877008 Fax: +82-31-7874051
Received: July 22, 2019
Peer-review started: July 22, 2019
First decision: August 27, 2019
Revised: September 3, 2019
Accepted: September 11, 2019
Article in press: September 11, 2019
Published online: October 7, 2019
Processing time: 69 Days and 12.7 Hours
ARTICLE HIGHLIGHTS
Research background

Pancreatic cancer (PC) is usually diagnosed at advanced stages, resulting in the poor prognosis. Large-cohort studies should be performed to evaluate epidemiology and prognosis of PC. However, there are not enough researches about the accuracy of administrative database to avoid coding discrepancies. This study identified accuracy of the administrative large-cohort database of PC. This study is important to support the validation of other large cohort study for PC.

Research motivation

Administrative database was useful for research because of easy access and much information. So, administrative database has been widely used for medical research. However accuracy of the administrative database may be problem. In addition, it was difficult to perform study to identify this. We tried to examine each case and prove accuracy of database of PC. Future study using administrative database of PC should be supported by this study.

Research objectives

We evaluated the accuracy and usefulness of administrative database in PC. In addition, we identified much the doctors insert the accurate ICD codes for PC with location.

Research methods

We evaluated the diagnostic accuracy of PC according to tumor sites from total of 1846 cases with PC and controls. To enhance the study reliability, three reviewers carefully examined medical records and compared the final decisions for each case. After reviewing, we calculated the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). In addition, we analyzed patients with ICD 10-code of PC with primary location.

Research results

Among PC, 1428 (77.4%) cases were registered as unspecified PC, and only 410 (22.2%) cases could be identified with specific cancer sites. For overall diagnostic criteria of PC, the sensitivity and specificity of ICD-10 codes for PC were 99.95% and 98.72%, respectively. The PPV and NPV were 98.70% and 99.95%, respectively.

Research conclusions

We showed accuracy of administrative database of PC in seoul national university Bundang hospital. In addition, we identified the location of PC to usefulness of database. Administrative database is useful and important for research. However, validation of database is necessary. From this result, study based on administrative database might be reliable. Future study with administrative database of PC could receive credibility from this result. In addition, this study presented a research method how to identify validation of administrative database.

Research perspectives

We thought that future study involved multiple institute should be planned. In addition, it is important to gather data in a unified way. We think there is a need for researches for accuracy of administrative database on other disease. These researches should be necessary for studies base on administrative database.