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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Long-term outcomes of endoscopic resection for small (≤ 4.0 cm) gastric gastrointestinal stromal tumors originating from the muscularis propria layer
Yu Zhang, Xin-Li Mao, Xian-Bin Zhou, Hai Yang, Lin-Hong Zhu, Guang Chen, Li-Ping Ye
Yu Zhang, Xin-Li Mao, Xian-Bin Zhou, Li-Ping Ye, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Hai Yang, Department of Radiology, Enze Hospital, Wenzhou Medical University, Taizhou city 318000, Zhejiang Province, China
Lin-Hong Zhu, Department of Medical Administration, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Guang Chen, Department of Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Author contributions: Ye LP performed and analyzed the endoscopy operation; Zhang Y designed the study and drafted the manuscript; Mao XL performed postoperative management; Zhou XB and Zhu LH enrolled patients and acquired the follow-up data; Yang H and Chen G acquired the follow-up data.
Supported by A Project of the Health and Family Planning Commission of Zhejiang Province, No. 2016KYA192.
Institutional review board statement: The study was reviewed and approved by the Institutional Medical Ethics Review Board of Taizhou Hospital of Zhejiang Province.
Informed consent statement: All participants provided informed consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The STROBE Statement have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Li-Ping Ye, MBBS, Chief Doctor, Professor, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, 150 Ximen Street, Linhai 317000, Zhejiang Province, China.
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Received: April 13, 2018
Peer-review started: April 14, 2018
First decision: May 21, 2018
Revised: June 15, 2018
Accepted: June 25, 2018
Article in press: June 25, 2018
Published online: July 21, 2018
Processing time: 96 Days and 15.7 Hours
ARTICLE HIGHLIGHTS
Research background
The long-term effectiveness of endoscopic resection for small gastric gastrointestinal stromal tumors originating from the muscularis propria layer (MP-GISTs) still remains debatable.
Research motivation
A larger sample size with a longer follow-up period were included to assess the long-term safety and efficacy of ER for gastric MP-GIST
Research objectives
Evaluate the long-term efficacy of ER for small gastric gastrointestinal stromal tumors originating from the muscularis propria layer.
Research methods
We retrospectively analyzed 229 consecutive patients with gastric MP-GISTs who underwent ER with a follow-up at least 36 mo, between June 2005 and February 2015. The main outcome measurements included complete resection rate, complications, and long-term follow-up outcomes.
Research results
The outcomes showed that 225 patients were actively followed-up. The remaining 4 patients were lost because of unrelated death. During the follow-up period, no residual, recurrent lesions, or distant metastasis were detected in any patients.
Research conclusions
Endoscopic resection seems to be an effective and safe method for gastric MP-GISTs ≤ 4.0 cm, and for some intermediate or high risk GISTs, adjuvant therapy might be required to reduce the risk of recurrence or metastasis.
Research perspectives
Endoscopic resection might be an effective and safe therapeutic method for patients with gastric MP-GISTs ≤ 4.0 cm, and for some patients with intermediate or high risk GISTs, adjuvant therapy (imatinib mesylate, etc.) and/or additional surgery might be required to reduce the risk of recurrence.
