Clinical significance of vascular endothelial growth factor expression and neovascularization in colorectal carcinoma

doi:10.3748/wjg.v9.i6.1227

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Jun 15, 2003 (publication date) through Apr 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Jun 15, 2003; 9(6): 1227-1230
Published online Jun 15, 2003. doi: 10.3748/wjg.v9.i6.1227

Clinical significance of vascular endothelial growth factor expression and neovascularization in colorectal carcinoma

Shu Zheng, Ming-Yong Han, Zuo-Xiang Xiao, Jia-Ping Peng, Qi Dong

Shu Zheng, Ming-Yong Han, Zuo-Xiang Xiao, Jia-Ping Peng, Qi Dong, Cancer Institute, Zhejiang University, Hangzhou 310009, Zhejiang Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Professor Shu Zheng, Cancer Institute, Zhejiang University, Hangzhou 310009, Zhejiang Province, China

Telephone: +86-571-87214404 Fax: +86-571-87214404

Received: March 2, 2003
Revised: March 24, 2003
Accepted: April 1, 2003
Published online: June 15, 2003

Abstract

AIM: To clarify the association of vascular endothelial growth factor (VEGF) and microvascular density (MVD) expression with the angiogenesis and prognosis of colorectal cancer.

METHODS: A total of 97 cases of colorectal carcinomas were examined by immunohistochemical staining (SP method), using anti-VEGF and anti-factor CD34⁺ monoclonal antibodies.

RESULTS: VEGF positive staining was obtained in 68 out of 97 cases (70.1%), and observed mainly in the cytoplasm of tumor cells, and also frequently in stromal cells. VEGF expression was more intense in poorly differentiated adenocarcinoma in comparison with others, but there was no significant correlation between VEGF expression and age, sex and stage. A significant correlation was found between the MVD and grades, and there was no significant relationship between the MVD and age, sex, and stage. The MVD in the VEGF positive group (68 cases) was higher than that in the negative group. Upon multivariate analysis, the significant variables were stage, tumor grade and MVD; VEGF expression was not an independent prognostic factor.

CONCLUSION: The expression of VEGF has a significant correlation with MVD; MVD expression has prognostic value but VEGF has not in colon cancer.

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