Published online Mar 15, 2003. doi: 10.3748/wjg.v9.i3.568
Revised: November 13, 2002
Accepted: November 19, 2002
Published online: March 15, 2003
AIM: To observe the preventive effects of combined therapy of AMD (allantoin, metronidazolem and dexamethasone in combination) on intra-abdominal adhesion in dogs.
METHODS: 20 dogs of both sexes were used in this study. After laparotomy under anesthesia, 2 cm section of cecal end was clamped and ligated, then 1 cm cecum section was cut and another 1 cm was kept. The cecum stump was closed with purse-string suture. Both parietal and visceral peritonea were stripped for an area of about 3 × 4 cm2. Before the skin closure, the animals were divided into two groups randomly. The abdominal cavities in Group AMD (n = 10) were rinsed by 200 mL of AMD solution, and with 50 mL left, whereas the control (n = 10) received the equal volume of normal saline. After 7 d, the degree of intra-abdominal adhesions was evaluated by using the score method of ultrasonography and traditional dissection.
RESULTS: Compared with the control, both the ultrasonography and traditional dissection scores in Group AMD were significantly decreased that marked as 2.0 ± 1.25 vs 3.3 ± 0.82 and 1.91 ± 0.83 vs 3.3 ± 0.82 respectively (P < 0.01).
CONCLUSION: The combined therapy of AMD is an effective way to prevent intra-abdominal adhesion, and ultrasonography is an useful tool to diagnose intra-abdominal adhesion.