Gastric Cancer
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 15, 2003; 9(3): 432-436
Published online Mar 15, 2003. doi: 10.3748/wjg.v9.i3.432
Prospective cohort study of comprehensive prevention to gastric cancer
Hai-Qiang Guo, Peng Guan, Hai-Long Shi, Xuan Zhang, Bao-Sen Zhou, Yuan Yuan
Hai-Qiang Guo, Peng Guan, Hai-Long Shi, Xuan Zhang, Bao-Sen Zhou, Department of Epidemiology, College of Public Health, China Medical University, Shenyang 110001, Liaoning Province, China
Yuan Yuan, Cancer Institute, The First Clinical Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: All authors contributed equally to the work.
Supported by National Ninth Five-year Study Program for Taking Key Scientific Problems, No.96-906-01-04, and National Tenth Five-year Study Program for Taking Key Scientific Problems, No. 2001BA703B06(B)
Correspondence to: Prof. Yuan Yuan, Cancer Institute, The First Clinical Hospital, China Medical University, Shenyang 110001, Liaoning Province, China. yyuan@mail.cmu.edu.cn
Telephone: +86-24-23256666-6292
Received: July 17, 2002
Revised: August 8, 2002
Accepted: November 4, 2002
Published online: March 15, 2003
Abstract

AIM: To evaluate the preliminary effects of comprehensive prevention of gastric cancer in Zhuanghe County epidemiologically.

METHODS: Stratified sampling and cluster sampling were applied to define the intervention group and the control group. The prospective cohort study was used for evaluating the effect of preventing gastric cancer. The relative risk (RR) and attributable risk percent (AR%) of intervention on gastric cancer death were calculated. Potential years of life lost (PLYY) of the disease was analyzed, and the RR and AR% of PYLL were calculated. Survival analysis was applied among the screened patients.

RESULTS: In the first 4 years after intervening, the relative risk (RR) of intervention on death was 0.5059 (95%CI: 0.3462-0.7392, P < 0.05) with significance statistically. AR% of the intervention on death was 49.41%. The RR of intervention on cumulative PYLL was 0.6778 (95%CI: 0.5604-0.8198, P < 0.05) with statistic significance. AR% of the intervention on cumulative PYLL was 30.32%. The four-year survival rate of the screened patients was 0.6751 (95%CI: 0.5298-0.9047).

CONCLUSION: The initiative intervention results showed that the intervention approach used in the trial was effective, it reduced mortality and increased survival rate, and alleviated the adverse effect of gastric cancer on the health and life of screened population.

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