Viral Hepatitis
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 15, 2003; 9(10): 2221-2225
Published online Oct 15, 2003. doi: 10.3748/wjg.v9.i10.2221
Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B
Ye-Gui Jiang, Yu-Ming Wang, Tong-Hua Liu, Jun Liu
Ye-Gui Jiang, Yu-Ming Wang, Jun Liu, Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Tong-Hua Liu, Department of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing 400038, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Ye-Gui Jiang, Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. jiangyegui@yahoo.com.cn
Telephone: +86-23-68754141 Fax: +86-23-68754479
Received: May 10, 2003
Revised: June 12, 2003
Accepted: June 19, 2003
Published online: October 15, 2003
Abstract

AIM: To investigate the association between the polymorphism of HLA-DRB1, -DQA1 and -DQB1 alleles and viral hepatitis B.

METHODS: HLA-DRB1, -DQA1 and -DQB1 alleles in 54 patients with chronic hepatitis B, 30 patients with acute hepatitis B and 106 normal control subjects were analyzed by using the polymerase chain reaction/sequence specific primer (PCR/SSP) technique.

RESULTS: The allele frequency of HLA-DRB1*0301 in the chronic hepatitis B group was markedly higher than that in the normal control group (17.31% vs 5.67%), there was a significant correlation between them (χ2 = 12.3068, Pc = 0.0074, RR = 4.15). The allele frequency of HLA-DQA1*0501 in the chronic hepatitis B group was significantly higher than that in the normal control group (25.96% vs 13.68%), there was a significant correlation between them (χ2 = 9.2002, Pc = 0.0157, RR = 2.87). The allele frequency of HLA-DQB1*0301 in the chronic hepatitis B group was notably higher than that in the normal control group (35.58% vs 18.87%), there was a significant correlation between them (χ2 = 15.5938, Pc = 0.0075, RR = 4.07). The allele frequency of HLA-DRB1*1101/1104 in the chronic hepatitis B group was obviously lower than that in the normal control group (0.96% vs 13.33%), there was a significant correlation between them (χ2 = 11.9206, Pc = 0.0145, RR = 18.55). The allele frequency of HLA-DQA1*0301 in the chronic hepatitis B group was remarkably lower than that in the normal control group (14.42% vs 30%), there was a significant correlation between them (χ2 = 8.7396, Pc = 0.0167, RR = 0.35).

CONCLUSION: HLA-DRB1*0301, HLA-DQA1*0501 and HLA-DQB1*0301 are closely related with susceptibility to chronic hepatitis B, and HLA-DRB1*1101/1104 and HLA-DQA1*0301 are closely related with resistance to chronic hepatitis B. These findings suggest that host HLA class II gene is an important factor determining the outcome of HBV infection.

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