15d-PGJ2 inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line

doi:10.3748/wjg.v9.i10.2149

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Oct 15, 2003 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Oct 15, 2003; 9(10): 2149-2153
Published online Oct 15, 2003. doi: 10.3748/wjg.v9.i10.2149

15d-PGJ₂ inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line

Yun-Xian Chen, Xue-Yun Zhong, Yan-Fang Qin, Wang Bing, Li-Zhen He

Yun-Xian Chen, Department of Hematology, the First Affiliated Hospital of Sun-Yat-Sen University, Guangzhou 510080, Guangdong Province, China

Xue-Yun Zhong, Yan-Fang Qin, Wang Bing, Li-Zhen He, Department of Pathology, Medical College, Jinan University, Guangzhou 510632, Guangdong Province, China

Author contributions: All authors contributed equally to the work.

Supported by Science Fund of Guangdong Province, No. 015012, Science Fund of Guangzhou, 2001-Z-01-2 and the State 973 Projects, 2002ccc0400

Correspondence to: Dr. Xue-Yun Zhong, Department of Pathology, Medical College, Jinan University, Guangzhou 510632, Guangdong Province, China. tzxy@jnu.edu.cn

Telephone: +86-20-85220252

Received: April 8, 2003
Revised: May 12, 2003
Accepted: May 19, 2003
Published online: October 15, 2003

Abstract

AIM: To investigate the influence of peroxisome proliferator-activated receptor γ (PPARγ) ligand, 15-deoxy-△12, 14-prostaglandin J₂ (15dPGJ₂) on the proliferation and apoptosis of MCG-803 human gastric cancer cell lines.

METHODS: Cell proliferation was measured by ³H-TdR assay. Apoptosis was determined by ELISA and TUNEL staining. Protein and mRNA level of bcl-2 family and COXs were measured by Western blotting and Northern blotting respectively. PGE₂ production was examined by RIA.

RESULTS: 15dPGJ₂ inhibited cell growth and induced apoptosis of MCG-803 cells. The COX-2 and bcl-2/bax ratios were decreased following 15dPGJ₂ treatment. The PGE₂ production in supernatants was also decreased. These changes were in a dose-dependent manner.

CONCLUSION: 15dPGJ₂ may be a useful therapeutic agent for the treatment of gastric cancer.

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