Relationship between the imaging features and pathologic alteration in hepatoma of rats

doi:10.3748/wjg.v9.i1.69

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Jan 15, 2003; 9(1): 69-72
Published online Jan 15, 2003. doi: 10.3748/wjg.v9.i1.69

Relationship between the imaging features and pathologic alteration in hepatoma of rats

Jia-He Yang, Tian-Geng You, Nan Li, Qi-Jun Qian, Ping Wang, Zhen-Lin Yan, Meng-Chao Wu

Jia-He Yang, Tian-Geng You, Nan Li, Qi-Jun Qian, Ping Wang, Zhen-Lin Yan, Meng-Chao Wu, Eastern Heptobiliary Hospital, 225 Changhai Road, Shanghai 200433, China

Author contributions: All authors contributed equally to the work.

Supported by two National Natural Science Foundation of China, No. 39870760 and No. 39970838

Correspondence to: Dr. Jie-He Yang, Department of Comprehensive Treatment III, Eastern Heptobiliary Hospital, Second Military Medical University, Changhai Road 225, Shanghai 200433, China. tgyou59@hotmail.com

Telephone: +86-21-25070786 Fax: +86-21-65562400

Received: December 5, 2001
Revised: February 2, 2002
Accepted: February 23, 2002
Published online: January 15, 2003

Abstract

AIM: The imaging features of MRI and DSA, using the models of implanted and induced hepatoma, were investigated in rats.

METHODS: CBRH3 cancer cells were implanted for different liver site of rat liver and the diethylnitrosoamine was given orally to rats in order to induce liver cancer. Both experimental groups were detected by magnetic resonance imaging (MRI), digital subtraction angiography (DSA) and morphologic assay.

RESULTS: Hypointensity on T1WI and homogenous high signal intensity on T2WI in MRI, and ring-like abnormal stain on DSA were found in implanted cancer. Induced cancers appeared as homogeneous or heterogeneous hypointensity on T1WI (10 cases), and equal or slight high intensity on T2WI (8 cases), but some as hypointensity on T2WI (2 cases).

CONCLUSION: The imaging features of implanted cancers were similar to that of human liver metastases. Therefore, it could serve as an experimental model of human liver metastatic tumor. The imaging feature of induced cancers, whereas, were similar to that of human primary liver cancer. It could be use as an experimental model of human primary liver cancer.

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