Gastric Cancer
Copyright ©The Author(s) 2002. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 15, 2002; 8(6): 1005-1008
Published online Dec 15, 2002. doi: 10.3748/wjg.v8.i6.1005
Mast cell density and the context of clinicopathological parameters and expression of p185, estrogen receptor, and proliferating cell nuclear antigen in gastric carcinoma
Ying-An Jiang, You-Yuan Zhang, He-Sheng Luo, Shou-Fu Xing
Ying-An Jiang, He-Sheng Luo, Department of Gastroenterology, Renming Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
You-Yuan Zhang, Department of Pathology, Central Hospital of Huangshi City, Huangshi 435000, Hubei Province, China
Shou-Fu Xing, Department of Pathology, Medical College of Wuhan University, Wuhan 430071, Hubei Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Ying-An Jiang, Central Hospital of Huangshi City, 43 Wuhan Road, Huangshi 435000, Hubei Province, China. hszxyy@public.hs.hb.cn
Telephone: +86-714-6283783 Fax: +86-714-6233931
Received: April 26, 2002
Revised: May 29, 2002
Accepted: June 10, 2002
Published online: December 15, 2002
Abstract

AIM: To investigate the relationship between the mast cell density (MCD) and the context of clinicopathological parameters and expression of p185, estrogen receptor (ER), and proliferating cell nuclear antigen (PCNA) in gastric carcinoma.

METHODS: Mast cell, p185, ER, and PCNA were detected using immunohistochemical S-P labeling method. Mast cell was counted in tissue of gastric carcinoma and regional lymph nodes respectively, and involved lymph nodes (ILN) were examined as usual.

RESULTS: MCD was significantly related to both age and depth of penetration (χ2 = 4.688,P < 0.05 for age and χ2 = 9.350, P < 0.01 for depth of penetration) between MCD > 21/0.03 mm2 and MCD ≤ 21/0.03 mm2 in 100 patients; MCD in 1-6 ILN group patients was significantly higher than that in 7-15 ILN or > 15 ILN group patients (u = 6.881, 8.055, P < 0.01); There were significant differences intergroup in positive expression rate of p185, ER and PCNA between MCD > 21/ 0.03 mm2 and MCD ≤ 21/0.03 mm2 in 100 patients.

CONCLUSION: Mast cell may have effect on inhibiting invasive growth of tumor, especially in the aged patients; The number of mast cells, in certain degree, may predicate the number of involved lymph nodes, which is valuable for assessment of prognosis; MCD was related to the expression of p185, ER, and PCNA in gastric carcinoma. It suggests that mast cell accumulation may inhibit the proliferation and the dissemination of the gastric carcinoma.

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