Original Articles
Copyright ©The Author(s) 2001. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 2001; 7(1): 74-79
Published online Feb 15, 2001. doi: 10.3748/wjg.v7.i1.74
Comparison of a new stent and Wallstent for transjugular intrahepatic portosystemic shunt in a porcine model
Gao Jun Teng, Michael A. Bettmann, P. Jack Hoopes, Li Yang
Gao Jun Teng, Department of Radiology, Zhong-Da Hospital, Southeast University, Nanjing 210009, China
Michael A. Bettmann, P. Jack Hoopes, Department of Radiology, Dartmouth-Hitchcock Medical Center, USA
Li Yang, Department of Radiology, PLA General Hospital, Beijing
Author contributions: All authors contributed equally to the work.
Correspondence to: Gao Jun Teng, M.D., Department of Radiology, Zhong-Da Hospital, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China. gjteng@public1.ptt.js.cn
Telephone: 0086-25-3311083 Fax: 0086-25-3311083
Received: April 3, 2000
Revised: July 23, 2000
Accepted: July 30, 2000
Published online: February 15, 2001
Abstract

AIM: To evaluate a new balloon-expandable stainless steel stent (Cordis stent) in a transjugular intrahepatic portosystemic shunt (TIPS) porcine model and compared with Wallstent.

METHODS: TIPS was performed in 26 normal domestic pigs weighing 20 kg-30 kg using a Cordis stent or Wallstent (13 pigs in each stent). All pigs were sacrificed at the 14th day after TIPS. The stent deployment delivery system, stent patency, and stent recoil after placement were evaluated.Proliferative response in representative histological sections from the center, hepatic and portal regions of the two stent designs were quantified.

RESULTS: The shunt was widely patent in 4 pigs in the Cordis stent group (4/12, premature dead in 1 pig), and in 5 pigs in the Wallstent group (5/13). All remaining stents of both designs were occluded or stenotic. The mean quantified proliferation including thickness of the proliferation and the ratio of proliferation: total area in three assayed regions in Cordis stent and Wallstent was 2.18 mm2 2:00 mm, and 59.18 mm2. 51.66 mm2, respectively (P < 0.05). The delivery system and mechanical properties of the Cordis stent fuctioned well.

CONCLUSION: The new Cordis stent is appropriate for TIPS procedure.

Keywords: hypertention/portal; portosystemic shunt/surgical; stents; radiology/interventional; balloon dilatation; swine