Original Articles
Copyright ©The Author(s) 2000. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 15, 2000; 6(4): 501-507
Published online Aug 15, 2000. doi: 10.3748/wjg.v6.i4.501
Study on relationship of nitric oxide, oxidation, peroxidation, lipoperoxidation with chronic chole-cystitis
Jun-Fu Zhou, Dong Cai, You-Gen Zhu, Jin-Lu Yang, Cheng-Hong Peng, Yang-Hai Yu
Jun-Fu Zhou, Dong Cai, Cheng-Hong Peng, Yang-Hai Yu, The Second Affiliated Hospital of Medical College of Zhejiang University, Hangzhou 310009, Zhejiang Province, China
You-Gen Zhu, Jin-Lu Yang, The People’s Hospital of Jinhua City, Jinhua 321000, Zhejiang Province, China
Jun-Fu Zhou, M.D, male, born on 1945-03-07 in Hangzhou, Zhejiang Province, graduated from Zhejiang Medical University, having 150 papers published and having won 10 Advanced Prizes in Science and Technology from Zhejiang Province People’s Government and PLA
Author contributions: All authors contributed equally to the work.
Correspondence to: Prof. Jun-Fu Zhou, The Second Affiliated Hospital of Medical College of Zhejiang University, 68 Jiefang Road, Hangzhou 310009, Zhejiang Province, China
Telephone: +86-571-778-3768 or 605-2515 Fax: +86-571-721-3864
Received: February 12, 2000
Revised: February 26, 2000
Accepted: March 5, 2000
Published online: August 15, 2000
Abstract

AIM: To study relationship of injury induced by nitric oxide, oxidation, peroxidation, lipoperoxidation with chronic cholecystitis.

METHODS: The values of plasma nitric oxide (P-NO), plasma vitamin C (P-VC), plasma vitamin E (P-VE), plasma β-carotene (P-β-CAR), plasma lipoperoxides (P-LPO), erythrocyte superoxide dismutase (E-SOD), erythrocyte catalase (E-CAT), erythrocyte glutathione peroxidase (E-GSH-Px) activities and erythrocyte lipoperoxides (E-LPO) level in 77 patients with chro nic cholecystitis and 80 healthy control subjects were determined, differences of the above average values between t he patient group and the control group and differences of the average values bet ween preoperative and postoperative patients were analyzed and compared, linear regression and correlation of the disease course with the above determination values as well as the stepwise regression and correlation of the course with th e values were analyzed.

RESULTS: Compared with the control group, the average values of P-NO, P-LPO, E-LPO were significantly increased (P < 0.01), and of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT and E-GSH-Px decreased (P < 0.01) in the patient group. The analysis of the lin ear regression and correlation s howed that with prolonging of the course, the values of P-NO, P-LPO and E-LPO in the patients were gradually ascended and the values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT and E-GSH-Px descended (P < 0.01). The analysis of the stepwise regression and correlation indicated that the correlation of the course with P-NO, P-VE and P-β-CAR values was the closest. Compared with the preoperative patients, the average values of P-NO, P-LPO and E-LPO were significantly decre ased (P < 0.01) and the average values of P-VC, E-SOD, E-CAT and E-GSH-Px in postoperative pa tients increased (P < 0.01) in postoperative patients. But there was no signif icant difference in the average values of P-VE, P-β-CAR preope rative and postoperative patients.

CONCLUSION: Chronic cholecystitis could induce the increase of nitric oxide, oxidation, peroxidation and lipoperoxidation.

Keywords: nitric oxide, oxidation, peroxidation, lipoperoxidation, chronic cholecystitis