Zhan WH, Ma JP, Peng JS, Gao JS, Cai SR, Wang JP, Zheng ZQ, Wang L. Telomerase activity in gastric cancer and its clinical implications. World J Gastroenterol 1999; 5(4): 316-319 [PMID: 11819456 DOI: 10.3748/wjg.v5.i4.316]
Corresponding Author of This Article
Professor Wen-Hua Zhan, Department of Surgery, The First Affiliated Hospital, Sun Yat Sen University of Medical Sciences, Guangzhou, China. whzhan@gzsums.edu.cn
Article-Type of This Article
Original Articles
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World J Gastroenterol. Aug 15, 1999; 5(4): 316-319 Published online Aug 15, 1999. doi: 10.3748/wjg.v5.i4.316
Telomerase activity in gastric cancer and its clinical implications
Wen-Hua Zhan, Jin-Ping Ma, Jun-Sheng Peng, Jing-Song Gao, Shi-Rong Cai, Jian-Ping Wang, Zhang-Qing Zheng, Lei Wang
Wen-Hua Zhan, Jin-Ping Ma, Jun-Sheng Peng, Jing-Song Gao, Shi-Rong Cai, Jian-Ping Wang, Zhang-Qing Zheng, Lei Wang, Department of Surgery, Sun Yat-Sen University of Medical Sciences, the First Affiliated Hospital, Guangzhou, China
Author contributions: All authors contributed equally to the work.
Supported by the research grant from Natural Science Foundation of Guangdong Province and Public Health Commission of Guangdong Province
Correspondence to: Professor Wen-Hua Zhan, Department of Surgery, The First Affiliated Hospital, Sun Yat Sen University of Medical Sciences, Guangzhou, China. whzhan@gzsums.edu.cn
Received: January 20, 1999 Revised: March 3, 1999 Accepted: April 19, 1999 Published online: August 15, 1999
Abstract
AIM: To study the telomerase expression in gastric carcinoma and its clinical implications.
METHODS: Telomerase activity was examined in gastric cancer an d corresponding normal tissues using a modified TRAP (telomeric repeat amplification protocol) assay (TRAP-eze) in tissue samples from 94 gastric carcinomas an d 58 normal tissues, 12 gastric adenomas and 9 gastric ulcer lesions.
RESULTS: Telomerase activity was present in 81 of the 94 (86.2%) gastric cancer tissues, whereas no telomerase activity was detected in any normal tissues. The incidence of telomerase activity in gastric cancer tissues was unrelated to the tumor diameter, histological grade, tumor invasion in depth, lymph node metastasis and TNM stage.
CONCLUSION: Telomerase plays an important role in carcinogenes is and progression of gastric cancer, and it is suggested to be a useful tumor marker.
