Published online Aug 15, 1999. doi: 10.3748/wjg.v5.i4.308
Revised: July 3, 1999
Accepted: July 19, 1999
Published online: August 15, 1999
AIM: To evaluate the safety and efficacy of the bioartificial liver support system in canines with acute liver failure (ALF).
METHODS: Nine canines with acute liver failure by acetaminophen -induced received TECA- I bioartificial liver support system (BALSS) from Hong Kong TECA LTD Co. Blood was perfused through a hollow fiber tube containing (1.2) × 1010 the porcine hepatocytes. In contrast, another 10 canines with a cute liver failure by Acetaminophen received drugs. Each treatment lasted 6 h.
RESULTS: BALSS treatment resulted in beneficial effects for acetaminophen-induced ALF canines with survival and with the recovery of the live r functions and tissues, and plasma ammonia decreased from 135.9 μmol/L ± 17.5 μmol/L to 65.7 μmol/L ± 22.0 μmol/L, 32.5 μmol/L ± 8.8 μmol/L, GPT from 97.8 U/L ± 8.7 U/L to 64.8 U/L ± 11.9 U/L, 19.0 U/L ± 6.3 U/L, GOT from 103.0 U/L ± 16.7 U/L to 75.7 U/L ± 19.6 U/L, 26.5 U/L ± 5.0 U/L, and AKP from 158.3 U/L ± 12.1 U/L to 114.5 U/L ± 19.8 U/L, 43.8 U/L ± 5.6 U/L during and after the treatment. In contrast, 10 ALF canines in both the drug and control groups died 1 or 2 d after treatment.
CONCLUSION: TECA-1 artificial liver support system is safe and efficacious for canines with acute liver failure.