Combined Traditional and Modera Medicine
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 15, 1998; 4(4): 357-359
Published online Aug 15, 1998. doi: 10.3748/wjg.v4.i4.357
Traditional Chinese medicine "Qing Yi Tang" alleviates oxygen free radical injury in acute necrotizing pancreatits
Zhan-Liang Li, Cheng-Tang Wu, Lian-Rong Lu, Xiao-Feng Zhu, De-Xin Xiong
Zhan-Liang Li, Lian-Rong Lu, Xiao-Feng Zhu, De-Xin Xiong, 304th Hospital of PLA, Beijing 100037, China
Cheng-Tang Wu, Nanfang Hospital, First Military Medical University, Guangzhou 510515, Guangdong Province, China
Zhan-Liang Li, MD, male, born on Oct. 26, 1933 in Guangdong Province, China, graduated from Kharkov Medical School, Ukraine, in 1960, now professor of surgery, having more than 80 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Zhan-Liang Li, 304th Hospital of PLA, 51 Fucheng Rd, Beijing 100037, China
Telephone: +86-10-68471161 Fax: +86-10-68429998
Received: March 8, 1998
Revised: April 25, 1998
Accepted: June 11, 1998
Published online: August 15, 1998
Abstract

AIM: To observe the changes in oxygen free radical (OFR) and the curative effect of traditional Chinese medicine “Qing Yi Tang” in acute necrotizing pancreatitis (ANP).

METHODS: After induction of ANP by injection of sodium taurocholate into pancreatic duct, 16 dogs were randomly divided into control group and Chinese medicine group. Serum amylase, SOD and MDA were determined on postoperative day 1, 2, 4 and 7. The animals were sacrificed on day 7. SOD and MDA in organs were determined, and pathological changes in pancreas were observed.

RESULTS: As compared with control group, the serum level of amylase (734 U/L vs 2783 U/L) and MDA (7.8 nmol/mL vs 14.8 nmol/mL) in Chinese medicine group were decreased on day 7 (P < 0.05), while SOD increased significantly (281 nU/mL vs 55 nU/mL, P < 0.01), and similar changes occurred in MDA and SOD in organs, especially in the pancreas; the pathological changes in the pancreas were alleviated as well.

CONCLUSION: “Qing Yi Tang” is effective in clearing OFRs and alleviating pathological changes in ANP.

Keywords: pancreatitis/therapy; Qing Yi Tang; free radicals; superoxide dismutase/analysis; malonyldiadehyde/ analysis