Calculus bovis inhibits liver cancer via the Wnt/β-catenin pathway

doi:10.3748/wjg.v31.i9.99459

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Mar 7, 2025 (publication date) through Feb 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 7, 2025; 31(9): 99459
Published online Mar 7, 2025. doi: 10.3748/wjg.v31.i9.99459

Calculus bovis inhibits liver cancer via the Wnt/β-catenin pathway

Jian-Qiang Chen, Xiang Lan

Jian-Qiang Chen, Xiang Lan, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Author contributions: Chen JQ gathered the data and wrote the manuscript; Lan X edited and reviewed the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Xiang Lan, MD, Doctor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China. lanxiangkeyan@163.com

Received: July 23, 2024
Revised: January 8, 2025
Accepted: January 18, 2025
Published online: March 7, 2025
Processing time: 210 Days and 3.2 Hours

Abstract

In this paper, the mechanism of the Wnt/β-catenin pathway is introduced, and the process and principle of the experiment conducted by Huang et al is explained. We discussed the reliability of the conclusion that Calculus bovis (C. bovis) inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer. We also offer suggestions for further studies of the use of C. bovis in the treatment of liver cancer.

Keywords: Calculus bovis; Liver cancer; Wnt; β-catenin; M2 macrophage polarization

Core Tip: We introduce the process and principle of the experiment conducted by Huang et al and discuss the reliability of the conclusion that Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer.