Paramythiotis D, Tsavdaris D, Karlafti E. GATIS score: An innovative prognostic score for rectal neuroendocrine neoplasms. World J Gastroenterol 2025; 31(6): 100458 [DOI: 10.3748/wjg.v31.i6.100458]
Corresponding Author of This Article
Daniel Paramythiotis, Doctor, Full Professor, 1st Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, St. Kyriakidi 1, Thessaloniki 54636, Greece. danosprx@auth.gr
Research Domain of This Article
Surgery
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Feb 14, 2025; 31(6): 100458 Published online Feb 14, 2025. doi: 10.3748/wjg.v31.i6.100458
GATIS score: An innovative prognostic score for rectal neuroendocrine neoplasms
Daniel Paramythiotis, Dimitrios Tsavdaris, Eleni Karlafti
Daniel Paramythiotis, Dimitrios Tsavdaris, 1st Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece
Eleni Karlafti, Department of Emergency, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece
Eleni Karlafti, 1st Propaedeutic Department of Internal Medicine, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece
Author contributions: Paramythiotis D designed the research; Tsavdaris D and Karlafti E performed the research and analyzed data; Paramythiotis D wrote the letter; Tsavdaris D and Karlafti E revised the letter.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Daniel Paramythiotis, Doctor, Full Professor, 1st Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, St. Kyriakidi 1, Thessaloniki 54636, Greece. danosprx@auth.gr
Received: August 16, 2024 Revised: November 11, 2024 Accepted: December 6, 2024 Published online: February 14, 2025 Processing time: 146 Days and 14.6 Hours
Abstract
In this article, we discussed the article by Zeng et al, published in a recent issue of the World Journal of Gastroenterology. The publication represents a significant advancement in the prognostic evaluation of rectal neuroendocrine neoplasms. The GATIS score is a single nomogram model that incorporates five key prognostic factors: Tumor grade; T stage; tumor size; age; and the prognostic nutritional index. This innovation optimizes the prognostic process, delivering more accurate predictions of overall survival and progression-free survival compared to traditional TNM staging and World Health Organization classification systems. The findings of the study were based on a retrospective analysis spanning 12 years and involving 1408 patients from 17 reference centers in China. In this editorial, we specifically examined the strengths and limitations of the study, the clinical implications of the GATIS score, and the questions arising from its conclusions.
Core Tip: The GATIS score enables a more robust prognostic evaluation of patients with rectal neuroendocrine neoplasms. This prognostic score evaluates key factors, such as tumor grade, T stage, tumor size, age, and the prognostic nutritional index, and surpasses traditional models in predicting overall and progression-free survival. This advancement highlights the value of personalized medicine and standardized prognostic evaluations in enhancing patient outcomes and clinical practice.
