Christodoulidis G, Tsagkidou K, Koumarelas KE, Kouliou MN. Advances and challenges in peroral endoscopic myotomy: Safety, precision, and post-procedure management. World J Gastroenterol 2025; 31(5): 97574 [DOI: 10.3748/wjg.v31.i5.97574]
Corresponding Author of This Article
Grigorios Christodoulidis, PhD, Executive Associate Editor-in-Chief, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. gregsurg@yahoo.gr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Grigorios Christodoulidis, Marina Nektaria Kouliou, Department of General Surgery, University Hospital of Larissa, Larissa 41110, Greece
Kyriaki Tsagkidou, Department of Gastroenterology, General Hospital of Larissa, Larisa 41221, Thessalía, Greece
Konstantinos Eleftherios Koumarelas, Department of Emergency Medicine, General Hospital of Larissa, Larissa 41221, Greece
Author contributions: Christodoulidis G designed the overall concept and outline of the manuscript; Christodoulidis G, Tsagkidou K, Koumarelas KE and Kouliou MN contributed to the discussion, manuscript design, the writing, editing the manuscript, and review of literature; All authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The authors declare no conflict of interest in publishing the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Grigorios Christodoulidis, PhD, Executive Associate Editor-in-Chief, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. gregsurg@yahoo.gr
Received: June 2, 2024 Revised: November 12, 2024 Accepted: December 4, 2024 Published online: February 7, 2025 Processing time: 210 Days and 13.9 Hours
Abstract
Peroral endoscopic myotomy (POEM) has revolutionized the treatment of upper gastrointestinal tract motility disorders, particularly achalasia. This editorial explores the efficacy, safety, and challenges of POEM, emphasizing its role as a primary treatment with excellent long-term outcomes and minimal adverse events. The evolution of POEM underscores the need for precision in myotomy techniques and the importance of interdisciplinary collaboration, especially regarding anesthetic considerations. Despite significant advances, challenges remain in standardizing safety protocols and managing complications. As POEM applications expand, precision endoscopy continues to enhance therapeutic outcomes, promising a transformative impact on gastrointestinal motility disorder management.
Core Tip: Peroral endoscopic myotomy (POEM) has emerged as a transformative treatment for upper gastrointestinal motility disorders, offering significant long-term efficacy with minimal adverse events. Keys to its success include precision in myotomy techniques, interdisciplinary collaboration for enhanced safety, and ongoing efforts to standardize protocols and manage complications. As POEM techniques advance and applications broaden, they promise to revolutionize the management of motility disorders.
