Liu QW, Liu L, Hu JX, Hou JQ, He WB, Shu YS, Wang XL. Nomogram based on a novel nutritional immune-inflammatory status score to predict postoperative outcomes in esophageal squamous cell carcinoma. World J Gastroenterol 2025; 31(4): 101749 [PMID: 39877711 DOI: 10.3748/wjg.v31.i4.101749]
Corresponding Author of This Article
Xiao-Lin Wang, Department of Thoracic Surgery, Northern Jiangsu People's Hospital, No. 98 Nantong West Road, Yangzhou 225000, Jiangsu Province, China. 18051063909@yzu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 28, 2025; 31(4): 101749 Published online Jan 28, 2025. doi: 10.3748/wjg.v31.i4.101749
Nomogram based on a novel nutritional immune-inflammatory status score to predict postoperative outcomes in esophageal squamous cell carcinoma
Qing-Wen Liu, Lin Liu, Jun-Xi Hu, Jia-Qi Hou, Wen-Bo He, Yu-Sheng Shu, Xiao-Lin Wang
Qing-Wen Liu, Jia-Qi Hou, Department of Graduate School, Dalian Medical University, Dalian 116000, Liaoning Province, China
Lin Liu, Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214000, Jiangsu Province, China
Jun-Xi Hu, Wen-Bo He, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu Province, China
Yu-Sheng Shu, Xiao-Lin Wang, Department of Thoracic Surgery, Northern Jiangsu People's Hospital, Yangzhou 225000, Jiangsu Province, China
Co-first authors: Qing-Wen Liu and Lin Liu.
Co-corresponding authors: Yu-Sheng Shu and Xiao-Lin Wang.
Author contributions: Liu QW and Liu L participated in the conception and design of the study and were involved in the acquisition, analysis, or interpretation of data; Liu QW and Liu L, who contributed equally to this paper, are co-first authors of the paper; Liu QW wrote the manuscript; Shu YS and Wang XL, the co-corresponding authors of the study, oversaw the design, analysis, and review of the research; Wang XL is the main contact person for this paper; all authors participated in the collection and review of the data; all authors were responsible for the decision to submit the manuscript for publication.
Supported by Jiangsu Provincial Health Commission Research Project on Elderly Health, No. LKZ2022019; Yangzhou Social Development and Clinical Frontier Technology Project, No. YZ2023084; and Yangzhou Innovation Capability Building Design Plan Project, No. YZ2022168.
Institutional review board statement: The Ethical Review Board of Northern Jiangsu People's Hospital approved the present study (Approval No. 2024ky317).
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: Data are available on request from the authors (18051063909@yzu.edu.cn).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Lin Wang, Department of Thoracic Surgery, Northern Jiangsu People's Hospital, No. 98 Nantong West Road, Yangzhou 225000, Jiangsu Province, China. 18051063909@yzu.edu.cn
Received: September 25, 2024 Revised: November 13, 2024 Accepted: December 6, 2024 Published online: January 28, 2025 Processing time: 96 Days and 0.3 Hours
Abstract
BACKGROUND
The relationship between patient nutritional, immune, and inflammatory status is linked to tumor progression and prognosis. However, there are limited studies on the prognosis of esophageal squamous cell carcinoma (ESCC) after surgery based on the comprehensive indicators of these factors.
AIM
To develop and validate a novel nomogram based on a nutritional immune-inflammatory status (NIIS) score for predicting postoperative outcomes in ESCC.
METHODS
This retrospective study examined 829 patients with ESCC who underwent radical surgery between June 2016 and June 2020, with 568 patients in the training cohort and 261 patients in the validation cohort. We incorporated comprehensive indicators related to nutrition, immunity, and inflammation to develop the NIIS score, using LASSO regression. Subsequently, a nomogram combining the NIIS score and other clinicopathological parameters was developed and validated using calibration curves, time-dependent area under curves, and decision curve analysis.
RESULTS
We identified eight indicators that constitute the NIIS score. High-risk scores emerged as an independent risk factor for overall survival [training set HR 2.497 (1.802, 3.458), P < 0.001]. A NIIS nomogram for personalized prognostic prediction was developed by integrating the NIIS score with clinicopathological variables, yielding enhanced predictive value relative to individual indicators and the UICC/TNM staging system.
CONCLUSION
The NIIS score provides strong predictive value for postoperative outcomes in ESCC, thus offering a valuable tool for clinical decision-making.
Core Tip: This retrospective, bicentric study aims to investigate the prognostic significance of comprehensive indicators related to nutrition, immunity, and inflammation in patients with esophageal squamous cell carcinoma (ESCC) following surgery. We incorporated these indicators to develop a novel nutritional immune-inflammatory status (NIIS) score. Additionally, we created and validated a nomogram based on the NIIS score and other clinicopathological parameters to predict post-surgical outcomes for patients with ESCC.
