Wei H, Mai ZL, Ma BT, Chang B. Creeping fat: A promising radiological predictor in small bowel Crohn’s disease. World J Gastroenterol 2025; 31(16): 105186 [DOI: 10.3748/wjg.v31.i16.105186]
Corresponding Author of This Article
Bing Chang, MD, PhD, Chief Physician, Professor, Department of Gastroenterology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. cb000216@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 28, 2025; 31(16): 105186 Published online Apr 28, 2025. doi: 10.3748/wjg.v31.i16.105186
Creeping fat: A promising radiological predictor in small bowel Crohn’s disease
Hong Wei, Zi-Ling Mai, Bo-Tong Ma, Bing Chang
Hong Wei, Zi-Ling Mai, Bo-Tong Ma, Bing Chang, Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Wei H wrote the original draft; Mai ZL, Ma BT and Chang B revised the manuscript; and all authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing Chang, MD, PhD, Chief Physician, Professor, Department of Gastroenterology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. cb000216@163.com
Received: January 18, 2025 Revised: March 7, 2025 Accepted: March 19, 2025 Published online: April 28, 2025 Processing time: 100 Days and 14.9 Hours
Abstract
In this manuscript, we comment on the article by Hasnaoui et al. Specifically, we delve into the characteristic manifestation of Crohn’s disease (CD) known as creeping fat (CF). Our primary focus is to investigate the potential of imaging features of CF in predicting the response of small bowel CD to biologic therapies and fecal microbiota transplantation. We believe that further research should be dedicated to developing methods for quantifying CF in order to provide more accurate predictive tools for the treatment of small bowel CD.
Core Tip: Creeping fat is a characteristic manifestation of Crohn’s disease (CD). We explored the relationship between creeping fat and gut microbiota and proposed potential significance of its radiological features in predicting the therapeutic response of small bowel CD to biological therapy and fecal microbiota transplantation. Although further validation is required, these findings can help establish precise predictive tools for CD treatment, thereby guiding personalized therapeutic strategies.
