Zheng T, Huang KY, Tang XD, Wang FY, Lv L. Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn’s disease. World J Gastroenterol 2025; 31(13): 104671 [DOI: 10.3748/wjg.v31.i13.104671]
Corresponding Author of This Article
Lin Lv, MD, Associate Chief Physician, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1 Xiyuan Playground, Haidian District, Beijing 100091, China. lushangshitou@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 7, 2025; 31(13): 104671 Published online Apr 7, 2025. doi: 10.3748/wjg.v31.i13.104671
Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn’s disease
Ting Zheng, Kai-Yue Huang, Xu-Dong Tang, Feng-Yun Wang, Lin Lv
Ting Zheng, Kai-Yue Huang, Graduate School, China Academy of Chinese Medical Sciences, Beijing 100091, China
Xu-Dong Tang, Feng-Yun Wang, Lin Lv, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China
Author contributions: Zheng T reviewed the literature and wrote the first draft of the paper; Huang KY contributed to searching the literature and edited it; Wang FY contributed to revising the paper; Tang XD conceived the idea and edited it; Lv L contributed to writing the paper, and edited it extensively.
Supported by the National Natural Science Foundation of China, No. 81873297; the Fundamental Research Funds for the Central Public Welfare Research Institutes, No. ZZ13-YQ-006; China Academy of Chinese Medical Sciences Innovation Fund, No. CI2021A01003; and the Hospital Capability Enhancement Project of Xiyuan Hospital, China Academy of Chinese Medical Sciences, No. XYZX0303-07.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin Lv, MD, Associate Chief Physician, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1 Xiyuan Playground, Haidian District, Beijing 100091, China. lushangshitou@qq.com
Received: December 28, 2024 Revised: February 20, 2025 Accepted: March 13, 2025 Published online: April 7, 2025 Processing time: 96 Days and 3.3 Hours
Abstract
Eukaryotic cells contain the endoplasmic reticulum (ER), a prevalent and intricate membranous structural system. During the development of inflammatory bowel disease (IBD), the stress on the ER and the start of the unfolded protein response are very important. Some chemicals, including 4μ8C, small molecule agonists of X-box binding protein 1, and ISRIB, work on the inositol-requiring enzyme 1, turn on transcription factor 6, and activate protein kinase RNA-like ER kinase pathways. This may help ease the symptoms of IBD. Researchers investigating the gut microbiota have discovered a correlation between ER stress and it. This suggests that changing the gut microbiota could help make new medicines for IBD. This study looks at how ER stress works and how it contributes to the emergence of IBD. It also talks about its possible clinical importance as a therapeutic target and looks into new ways to treat this condition.
Core Tip: Endoplasmic reticulum stress, as an important cell - responsive protective mechanism, plays a crucial role in maintaining the stability of the intracellular environment of intestinal cells in the highly prevalent inflammatory bowel disease. If the mechanisms by which it plays a key role can be accurately analyzed, there is great hope of opening up a new path for the treatment of inflammatory bowel disease.
