Published online Apr 7, 2025. doi: 10.3748/wjg.v31.i13.100863
Revised: February 22, 2025
Accepted: March 18, 2025
Published online: April 7, 2025
Processing time: 216 Days and 22.4 Hours
Effective acid suppression significantly enhances the eradication rate of Helicobacter pylori (H. pylori).
To assess the efficacy and safety of high-dose dual therapy (HDDT) utilizing va
The study population comprised untreated H. pylori patients from three medical centers in central China. From February 10, 2024 to March 31, 2024, 439 subjects were randomly allocated to either the esomeprazole-amoxicillin (EA) or esome
EA-dual demonstrated non-inferiority to B-quadruple regimen in modified intention-to-treat (mITT) and per-protocol (PP) analyses (P < 0.025). However, the eradication rate of EA was lower than that of the B-quadruple group [70.59% vs 83.49%, 92.86% vs 98.38%, 93.94% vs 98.38%, intention-to-treat (ITT), mITT, PP respectively, P < 0.05]. In ITT, mITT, and PP analyses, VA-dual was non-inferior to VAC treatment (84.15% vs 83.15%, 96.25% vs 92.73%, 96.75% vs 93.75%, P < 0.025). No significant differences were observed in adverse events, compliance, and symptom relief between groups. VA exhibited the lowest cost. Antibiotic use within 2 years, poor compliance, and suburban residence were associated with reduced eradication efficacy (P < 0.05).
The HDDT based on vonoprazan demonstrated non-inferiority to the VAC triple regimen, suggesting its potential as a recommended first-line treatment for H. pylori eradication. While B-quadruple therapy showed better eradi
Core Tip: The global burden of Helicobacter pylori infection is high. Triple and quadruple therapies are both classical regi