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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Antibiotic resistance of Helicobacter pylori and related risk factors in Hunan Province: A multicenter study
Jie Xie, Ming-Lin Zhang, Min Guo, Jian-Guo Li, Yuan Liu, Hong-Hui Chen, Fen Wang
Jie Xie, Ming-Lin Zhang, Fen Wang, Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
Jie Xie, Ming-Lin Zhang, Fen Wang, Hunan Key Laboratory of Non-resolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University, Changsha 410006, Hunan Province, China
Min Guo, Department of Gastroenterology, The First People’s Hospital of Changde, Changde 415003, Hunan Province, China
Jian-Guo Li, Department of Gastroenterology, The Fourth Hospital of Changsha, Changsha 410000, Hunan Province, China
Yuan Liu, Department of Gastroenterology, Yueyang Hospital of Traditional Chinese Medicine, Yueyang 414100, Hunan Province, China
Hong-Hui Chen, Department of Gastroenterology, The Second Affiliated Hospital of South China University, Hengyang 421099, Hunan Province, China
Co-first authors: Jie Xie and Ming-Lin Zhang.
Author contributions: Xie J, Zhang ML, Wang F, Guo M, Li JG, Liu Y, and Chen HH contributed to the methodology and resources; Xie J and Zhang ML made validation and formal analysis, wrote the original draft, and cured the data; Zhang ML and Wang F supervised the research; Wang F reviewed and edited the article; Xie J and Wang F acquired the funding; Guo M, Li JG, Liu Y, Chen HH, and Wang F conceptualized and administrated the project; Wang F is the corresponding author of the article; all authors have read and agreed to the published version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 82270594; and the Independent Exploration and Innovation Project of Central South University, No. 2024ZZTS0966.
Institutional review board statement: This study was conducted in accordance with the principles of the Declaration of Helsinki, and was approved by the Ethics Committee of the Third Xiangya Hospital of Central South University (No. 23259).
Informed consent statement: The requirement to obtain informed written consent was waived, because the study was retrospective and did not involve any privacy and commercial interests.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Data sharing statement: The data supporting the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Fen Wang, MD, Professor, Department of Gastroenterology, The Third Xiangya Hospital, Central South University, No. 138 Tongzi Road, Changsha 410013, Hunan Province, China.
wfen-judy@csu.edu.cn
Received: January 3, 2025
Revised: February 23, 2025
Accepted: March 6, 2025
Published online: March 28, 2025
Processing time: 82 Days and 16.5 Hours
BACKGROUND
Antibiotic resistance is a key factor influencing the treatment outcomes of Helicobacter pylori (H. pylori) infection. The antibiotic resistance spectrum of H. pylori varies in different regions. We investigated the current status of antibiotic resistance of H. pylori in Hunan Province and analyzed the factors related to such resistance to provide strategies for the accurate clinical treatment of H. pylori infection.
AIM
To understand the antibiotic resistance of H. pylori in Hunan Province and provide guidance for the clinical treatment of H. pylori infection.
METHODS
This study selected patients who underwent gastroscopy in five hospitals in Hunan Province from April 2022 to April 2023. The sensitivity of H. pylori to clarithromycin, levofloxacin, metronidazole, amoxicillin, furazolidone, and tetracycline was detected using the Agar dilution method.
RESULTS
H. pylori strains from a total of 566 patients were isolated and identified. The resistance rates of H. pylori strains to clarithromycin, levofloxacin, metronidazole, amoxicillin, furazolidone, and tetracycline were 49.2%, 37.8%, 76.1%, 2.3%, 1.4%, and 0.7%, respectively. The resistance rates to clarithromycin, levofloxacin, and metronidazole were high in the four regions of Hunan Province, and the overall resistance rates in central Hunan Province were higher than those in other regions. The resistance rates of H. pylori strains to clarithromycin and levofloxacin were significantly different among the different age groups (P < 0.05), with the elderly group having a higher resistance rate than the young group. The resistance rate of H. pylori strains to clarithromycin was greater in patients with atrophic gastritis, and the resistance rate to levofloxacin was the lowest in patients with peptic ulcers.
CONCLUSION
The resistance rate of H. pylori to amoxicillin, clarithromycin, and metronidazole is high in Hunan Province. Age, stomach disease, and H. pylori reinfection may affect the antibiotic resistance of H. pylori.
Core Tip: Antibiotic resistance is one of the main factors that determine the treatment effect of Helicobacter pylori (H. pylori) infection. The antibiotic resistance spectrum of H. pylori varies in different regions. We investigated the current status of antibiotic resistance of H. pylori in Hunan Province, and analyzed the related factors of such resistance, so as to provide strategies for accurate clinical treatment of H. pylori infection. The resistance rate of H. pylori to amoxicillin, clarithromycin, and metronidazole is high in Hunan Province, and age, stomach disease, and H. pylori reinfection may affect the antibiotic resistance of H. pylori.
