Zheng L, Ye ZY, Ma JJ. Effect of cholesterol metabolism on hepatolithiasis. World J Gastroenterol 2025; 31(1): 99960 [DOI: 10.3748/wjg.v31.i1.99960]
Corresponding Author of This Article
Jun-Ji Ma, MD, PhD, Associate Professor, Chief Physician, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. majunji@hebmu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 7, 2025; 31(1): 99960 Published online Jan 7, 2025. doi: 10.3748/wjg.v31.i1.99960
Effect of cholesterol metabolism on hepatolithiasis
Lin Zheng, Zi-Yu Ye, Jun-Ji Ma
Lin Zheng, Zi-Yu Ye, Jun-Ji Ma, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China
Author contributions: Zheng L contributed to conceptualization and drafted the paper; Ye ZY contributed to reviewing and editing; Zheng L and Ye ZY were involved in drafting the manuscript; Ma JJ reviewed and proofread the paper; All authors have read and approved the final version of the manuscript.
Supported by Hebei Natural Science Foundation, No. H2022206539; and Hebei Provincial Government Funded Clinical Talents Training Project, No. ZF2023143.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Ji Ma, MD, PhD, Associate Professor, Chief Physician, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. majunji@hebmu.edu.cn
Received: August 4, 2024 Revised: October 3, 2024 Accepted: November 5, 2024 Published online: January 7, 2025 Processing time: 127 Days and 5.7 Hours
Abstract
Surgical intervention is currently the primary treatment for hepatolithiasis; however, some patients still experience residual stones and high recurrence rates after surgery. Cholesterol metabolism seems to play an important role in hepatolithiasis pathogenesis. A high cholesterol diet is one of the significant reasons for the increasing incidence of hepatolithiasis. Therefore, regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after surgery. Reducing dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating hepatolithiasis. This article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis, as well as food intake and targeted therapeutic drugs.
Core Tip: Surgery is the primary treatment for hepatolithiasis. Although surgical methods are effective, increasing incidence and postoperative recurrence have become one of the complications in the diagnosis and treatment of hepatolithiasis. Therefore, understanding cholesterol metabolism and dietary and drug interventions to prevent the occurrence and development of hepatolithiasis are important.
