Jiang MJ, Wu MC, Duan ZH, Wu J, Xu XT, Li J, Meng QH. Prevalence and clinical impact of sarcopenia in liver transplant recipients: A meta-analysis. World J Gastroenterol 2024; 30(8): 956-968 [PMID: 38516245 DOI: 10.3748/wjg.v30.i8.956]
Corresponding Author of This Article
Qing-Hua Meng, MD, PhD, Doctor, Professor, Department of Hepatology, Beijing You-An Hospital, Capital Medical University, No. 8 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China. meng_qh0805@ccmu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Min-Jie Jiang, Mu-Chen Wu, Jing Wu, Xiao-Tong Xu, Juan Li, Qing-Hua Meng, Department of Hepatology, Beijing You-An Hospital, Capital Medical University, Beijing 100069, China
Zhong-Hui Duan, Department of Emergency, Beijing You-An Hospital, Capital Medical University, Beijing 100069, China
Co-first authors: Min-Jie Jiang and Mu-Chen Wu.
Author contributions: Jiang MJ, Wu MC, and Meng QH conceived and designed the experiments; Jiang MJ, and Wu MC analyzed the data; Duan ZH, Wu J, Xu XT, and Li J collected the information; Jiang MJ and Wu MC wrote the paper; Meng QH reviewed and edited the paper; all authors contributed to preparing the manuscript and approved the contents. Jiang MJ and Wu MC contributed equally to this work as co-first authors. The reasons for designating Jiang MJ and Wu MC as co-first authors are twofold. First, the research was performed as a collaborative effort, and the designation of co-corresponding authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the resultant paper. This also ensures effective communication and management of post-submission matters, ultimately enhancing the paper's quality and reliability. Second, Jiang MJ and Wu MC contributed efforts of equal substance throughout the research process. The choice of these researchers as co-corresponding authors acknowledges and respects this equal contribution, while recognizing the spirit of teamwork and collaboration of this study. In summary, we believe that designating Jiang MJ and Wu MC as co-first authors of is fitting for our manuscript as it accurately reflects our team's collaborative spirit, equal contributions, and diversity.
Conflict-of-interest statement: All authors have no conflict of interest.
PRISMA 2009 Checklist statement: This meta-analysis was conducted based on the PRISMA checklist and was registered in PROSPERO (CRD42022379765).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qing-Hua Meng, MD, PhD, Doctor, Professor, Department of Hepatology, Beijing You-An Hospital, Capital Medical University, No. 8 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China. meng_qh0805@ccmu.edu.cn
Received: October 16, 2023 Peer-review started: October 16, 2023 First decision: December 21, 2023 Revised: January 3, 2024 Accepted: February 1, 2024 Article in press: February 1, 2024 Published online: February 28, 2024 Processing time: 132 Days and 21.6 Hours
Abstract
BACKGROUND
The prevalence of sarcopenia in patients undergoing liver transplantation (LT) remains to be determined partly because of different diagnostic criteria. Sarcopenia has recently been recognized as a new prognostic factor for predicting outcomes in LT candidates.
AIM
To estimate the prevalence of sarcopenia and evaluate its clinical effect on LT candidates.
METHODS
This systematic search was conducted in PubMed, Web of Science, Embase, and Cochrane Library for original English-language articles that investigated the prevalence and influence of sarcopenia in patients undergoing LT from database inception to November 30, 2022. Cohort studies of the definition of sarcopenia that estimate sarcopenia prevalence and evaluate its effect on clinical outcomes and the risk of mortality were included.
RESULTS
Twenty-five studies involving 7760 patients undergoing LT were included. The pooled prevalence of sarcopenia in patients undergoing LT was 40.7% [95% confidence intervals (95%CI): 32.1–49.6]. The 1-, 3-, and 5-year cumulative probabilities of post-LT survival in patients with preoperative sarcopenia were all lower than those without sarcopenia (P < 0.05). Sarcopenia was associated with an increased risk of post-LT mortality in patients undergoing LT (adjusted hazard ratio: 1.58; 95%CI: 1.21–2.07). Patients with preoperative sarcopenia had a longer intensive care unit stay, a high risk ratio of sepsis, and serious post-LT complications than those without sarcopenia.
CONCLUSION
Sarcopenia is prevalent in a substantial proportion of patients undergoing LT and is strongly and independently associated with higher a risk of mortality risk.
Core Tip: The prevalence and effect of sarcopenia on patients undergoing liver transplantation (LT) remains to be determined partly because of different diagnostic criteria. Twenty-five studies involving 7760 patients undergoing LT were included in this meta-analysis. The pooled prevalence of sarcopenia in patients undergoing LT was 40.7%. Sarcopenia was associated with an increased risk of post-LT mortality in patients undergoing LT.
