Nguyen NTY, Luong TV, Nguyen DX, Le LD, Dang HNN. Understanding gastric metastasis of small cell lung carcinoma: Insights from case reports and clinical implications. World J Gastroenterol 2024; 30(47): 5092-5096 [DOI: 10.3748/wjg.v30.i47.5092]
Corresponding Author of This Article
Hai Nguyen Ngoc Dang, MD, Faculty of Medicine, Duy Tan University, 254 Nguyen Van Linh, Da Nang 550000, Viet Nam. ngochai123dc@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 21, 2024; 30(47): 5092-5096 Published online Dec 21, 2024. doi: 10.3748/wjg.v30.i47.5092
Understanding gastric metastasis of small cell lung carcinoma: Insights from case reports and clinical implications
Nhi Thi Y Nguyen, Thang Viet Luong, Dat Xuan Nguyen, Linh Duy Le, Hai Nguyen Ngoc Dang
Nhi Thi Y Nguyen, Thang Viet Luong, Dat Xuan Nguyen, Linh Duy Le, Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, Hue 530000, Viet Nam
Hai Nguyen Ngoc Dang, Faculty of Medicine, Duy Tan University, Da Nang 550000, Viet Nam
Co-corresponding authors: Thang Viet Luong and Hai Nguyen Ngoc Dang.
Author contributions: Nguyen NTY, Luong TV, and Nguyen DX generated the conception; Nguyen NTY, Luong TV, Nguyen DX, Le LD, and Dang HNN contributed to the writing, reviewing, editing, and drafting of the manuscript and approved the final version; Luong TV and Dang HNN are designated as co-corresponding authors due to their equally contributions; Luong TV oversaw data acquisition and statistical analyses; Dang HNN coordinated the cross-departmental collaboration and supervised manuscript revisions.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai Nguyen Ngoc Dang, MD, Faculty of Medicine, Duy Tan University, 254 Nguyen Van Linh, Da Nang 550000, Viet Nam. ngochai123dc@gmail.com
Received: September 5, 2024 Revised: October 11, 2024 Accepted: November 8, 2024 Published online: December 21, 2024 Processing time: 81 Days and 22.6 Hours
Abstract
Small cell lung cancer (SCLC) is a common type of primary lung cancer that contributes to approximately 15% of cases. It is closely associated with tobacco risk factors. It is also known as a type of lung cancer that has a high mortality rate within a short time due to its rapid growth rate (with tumor doubling time of 30 days) and its tendency to metastasize early in the disease process. The primary sites of metastasis in SCLC are similar to those in other primary lung cancers and often include the brain, bones, adrenal glands, liver, and lymph nodes. However, there are a few clinical reports of uncommon metastases, such as gastric metastasis from SCLC. Although the incidence of this clinical presentation is very low, reported cases have generally resulted in early mortality due to inadequate treatment. The purpose of this letter is to discuss the knowledge related to gastric metastasis from SCLC and remind clinical doctors not to miss atypical symptoms, thereby providing the right attitude to improve the prognosis for these patients.
Core Tip: Small cell lung cancer rapidly metastasizes to distant sites from early stages, but the stomach is not a common metastasis site. The rarity of this situation means that it is rarely reported, so the clinical doctor’s awareness of it is incomplete, resulting in inappropriate responses and poor clinical outcomes.
