Wang YB, Jin CZ. Roles of traditional Chinese medicine extracts in hyperuricemia and gout treatment: Mechanisms and clinical applications. World J Gastroenterol 2024; 30(47): 5076-5080 [PMID: 39713159 DOI: 10.3748/wjg.v30.i47.5076]
Corresponding Author of This Article
Chang-Zhong Jin, PhD, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. changzhongjin@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 21, 2024; 30(47): 5076-5080 Published online Dec 21, 2024. doi: 10.3748/wjg.v30.i47.5076
Roles of traditional Chinese medicine extracts in hyperuricemia and gout treatment: Mechanisms and clinical applications
Yan-Bo Wang, Chang-Zhong Jin
Yan-Bo Wang, Chang-Zhong Jin, Department of Cell Biology, Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250117, Shandong Province, China
Chang-Zhong Jin, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Wang YB and Jin CZ designed the overall concept and contributed to writing, editing and review of the literature.
Supported by Zhejiang Province Leading Geese Program, No. 2024C03218; and Research Project of Jinan Microecological Biomedicine Shandong Laboratory, No. JNL-2023010Q.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chang-Zhong Jin, PhD, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. changzhongjin@163.com
Received: July 31, 2024 Revised: October 23, 2024 Accepted: November 7, 2024 Published online: December 21, 2024 Processing time: 118 Days and 0.3 Hours
Abstract
In this manuscript, we comment on the article by Liu et al published in the recent issue of the journal. Hyperuricemia (HUA) has become the second most common metabolic disease after type 2 diabetes mellitus and is the most important risk factor for gout. This discussion focuses on the targets and clinical application value of traditional Chinese medicine (TCM) extracts in the treatment of HUA and gout, emphasizing the role of gut microbiota. Liu et al’s study demonstrated that Poecilobdella manillensis protein extract alleviated HUA through multiple mechanisms, including inhibition of uric acid (UA) reabsorption, promotion of UA excretion, repair of intestinal barrier function, and regulation of gut microbiota and metabolome. Unlike the commonly used urate-lowering drugs such as allopurinol and febuxostat, which have clear and single targets, many TCMs have multi-target effects. However, the active components and mechanisms of TCMs are not fully understood, limiting their clinical application in the treatment of HUA and gout. Additionally, the role of gut microbiota in UA metabolic homeostasis needs to be further explored.
Core Tip: Traditional Chinese medicines (TCMs) have significant potential in treating hyperuricemia (HUA), gout and other metabolic diseases. However, the “multi-target effects” do not fully explain the mechanisms of TCMs, hindering their clinical application. The active components and mechanisms of TCMs should be elucidated in detail. Additionally, the side effects of TCMs need attention. The role of gut microbiota in treating HUA also warrants further investigation to improve HUA and gout treatment strategies.
