Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2024; 30(47): 4983-4990
Published online Dec 21, 2024. doi: 10.3748/wjg.v30.i47.4983
Enhancing global hepatocellular carcinoma management: Bridging Eastern and Western perspectives on dexamethasone and N-acetylcysteine before transarterial chemoembolization
Thang Viet Luong, Nam Van Duc Nguyen, Linh Duy Le, Hieu Nguyen Hoang Minh, Hai Nguyen Ngoc Dang
Thang Viet Luong, Nam Van Duc Nguyen, Linh Duy Le, Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, Hue 530000, Viet Nam
Hieu Nguyen Hoang Minh, Department of Diagnostic Imaging, University of Medicine and Pharmacy, Hue University, Hue 530000, Viet Nam
Hai Nguyen Ngoc Dang, Faculty of Medicine, Duy Tan University, Da Nang 550000, Viet Nam
Co-first authors: Thang Viet Luong and Nam Van Duc Nguyen.
Author contributions: Luong TV, Nguyen NVD, and Le LD contributed to the conceptualization of the study and wrote the original draft of the manuscript. All authors contributed to writing, reviewing, editing, and drafting the manuscript and have read and approved the final version of the manuscript. As co-first authors, Luong TV led the data analysis and interpretation, while Nguyen NVD coordinated the research methodology and data collection, with each making essential contributions to the study’s completion.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai Nguyen Ngoc Dang, MD, Doctor, Lecturer, Researcher, Faculty of Medicine, Duy Tan University, No. 254 Nguyen Van Linh, Da Nang 550000, Viet Nam. ngochai123dc@gmail.com
Received: September 5, 2024
Revised: October 24, 2024
Accepted: November 13, 2024
Published online: December 21, 2024
Processing time: 81 Days and 22.8 Hours
Abstract

This article explores the integration of Eastern and Western perspectives on the use of dexamethasone and N-acetylcysteine as premedications in transarterial chemoembolization for hepatocellular carcinoma (HCC). By examining key concerns raised by Western researchers, particularly regarding the different etiologies of liver cirrhosis, and contrasting them with robust clinical data from Asia, this article highlights the necessity for region-specific research and proposes future directions for global HCC management.

Keywords: Hepatocellular carcinoma; Transarterial chemoembolization; Dexamethasone; N-acetylcysteine; East-West perspectives; Post-embolization syndrome

Core Tip: This editorial presents a critical assessment of the integration of dexamethasone and N-acetylcysteine in transarterial chemoembolization for hepatocellular carcinoma by juxtaposing Eastern and Western perspectives. It emphasizes the need for tailored treatment protocols that consider regional differences in disease etiology and healthcare practices, ensuring optimal patient outcomes across diverse populations.