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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Prognostic impact and reasons for variability by tumor location in gastric cancer
Yi-Xing Huang, Han-Yi He, Ken Chen, Hai-Dong Liu, Dan Zu, Chen Liang, Qi-Mei Bao, Yang-Chan Hu, Guo-Xia Liu, Yu-Ke Zhong, Chun-Kai Zhang, Ming-Cong Deng, Yan-Hua He, Ji Jing, Yin Shi, Sheng-Feng Xu, Yao-Shu Teng, Zu Ye, Xiang-Dong Cheng
Yi-Xing Huang, Han-Yi He, Ken Chen, Hai-Dong Liu, Dan Zu, Chen Liang, Qi-Mei Bao, Yang-Chan Hu, Guo-Xia Liu, Yu-Ke Zhong, Chun-Kai Zhang, Ming-Cong Deng, Yan-Hua He, Ji Jing, Zu Ye, Xiang-Dong Cheng, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou 310022, Zhejiang Province, China
Yi-Xing Huang, Yin Shi, School of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang Province, China
Han-Yi He, Hai-Dong Liu, Dan Zu, Chen Liang, Yan-Hua He, Ji Jing, Zu Ye, Xiang-Dong Cheng, Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province, Hangzhou 310022, China
Han-Yi He, Hai-Dong Liu, Dan Zu, Chen Liang, Yan-Hua He, Ji Jing, Zu Ye, Xiang-Dong Cheng, Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou 310022, China
Sheng-Feng Xu, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, United States
Yao-Shu Teng, Department of Otorhinolaryngology, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China
Co-corresponding authors: Zu Ye and Xiang-Dong Cheng.
Author contributions: Huang YX contributed to formal analysis, conceptualization, data curation, investigation, methodology, writing original draft, and writing-review & editing; He HY and Chen K contributed to formal analysis, conceptualization, and data curation; Liu HD, Zu D, Liang C, Bao QM, Hu YC, Liu GX, Zhong YK, Zhang CK, Deng MC, He YH, Jing J, Shi Y, Xu SF, and Teng YS contributed to investigation, methodology, and statistical analysis; Ye Z and Cheng XD contributed to writing-review and editing; and all authors have read and approved the final manuscript. Ye Z and Cheng XD contributed equally to this work as co-corresponding authors because both of them were involved in the conceptualization and design of the study, and both contributed significantly to the writing and revision of the manuscript, ensuring its scientific integrity and clarity.
Supported by the National Natural Science Foundation of China, No. 82473195; Natural Science Foundation of Zhejiang Province, No. LTGY23H160018; Zhejiang Medical and Health Science and Technology Program, No. 2024KY789; Beijing Science and Technology Innovation Medical Development Foundation, No. KC2023-JX-0270-07; and National Natural Science Foundation of China, No. 32370797.
Institutional review board statement: All study procedures, including animal care and handling, were approved by the Ethics Committee of Zhejiang Cancer Hospital (approval No. IRB-2024-604).
Informed consent statement: Informed consent was obtained from all participants involved in the study. Participants were provided with detailed information about the aims, methods, risks, benefits, and their rights to withdraw from the research at any time without penalty. All participants signed a consent form indicating their voluntary agreement to participate.
Conflict-of-interest statement: Author(s) certify that there is no conflict of interest related to the manuscript.
Data sharing statement: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Xiang-Dong Cheng, MD, Professor, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, No. 1 East Banshan Road, Hangzhou 310022, Zhejiang Province, China.
yezuqscx@gmail.com
Received: August 9, 2024
Revised: September 29, 2024
Accepted: October 22, 2024
Published online: November 28, 2024
Processing time: 94 Days and 23.7 Hours
BACKGROUND
Gastric cancer (GC) is a highly prevalent gastrointestinal tract tumor. Several trials have demonstrated that the location of GC can affect patient prognosis. However, the factors determining tumor location remain unclear.
AIM
To investigate the tumor location of patients, we went on to study the influencing factors that lead to changes in the location of GC.
METHODS
A retrospective evaluation was carried out on 3287 patients who underwent gastrectomy for GC in Zhejiang Cancer Hospital. The patients were followed up post-diagnosis and post-gastrectomy. The clinicopathological variables and overall survival of the patients were recorded. By analyzing the location of GC, the tumor location was divided into four categories: “Upper”, “middle”, “lower”, and “total”. Statistical software was utilized to analyze the relationship of each variable with the location of GC.
RESULTS
A total of 3287 patients were included in this study. The clinicopathological indices of gender, age, serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen (CA19-9) and CA72-4 levels, were significantly associated with tumor location in patients with GC. In addition, there was a strong correlation between GC location and the prognosis of postoperative patients. Specifically, patients with “lower” and “middle” GC demonstrated a better prognosis than those with tumors in other categories.
CONCLUSION
The five clinicopathological indices of gender, age, CEA, CA19-9 and CA72-4 levels exhibit varying degrees of influence on the tumor location. The tumor location correlates with patient prognosis following surgery.
Core Tip: This study investigates how the location of gastric cancer (GC) impacts prognosis by analyzing data from 3287 patients who underwent gastrectomy. It reveals that clinicopathological factors, including gender, age, and serum levels of carcinoembryonic antigen, carbohydrate antigen (CA) 19-9, and CA72-4, significantly influence tumor location. Notably, GC located in the “lower” and “middle” regions correlates with a better overall survival compared to other locations. These findings underscore the importance of tumor location in predicting patient outcomes and guiding postoperative management strategies.
