Kong MW, Yu Y, Wang P, Wan Y, Gao Y, Zhang CX. Advances in the research of intestinal fungi in Crohn's disease. World J Gastroenterol 2024; 30(39): 4318-4323 [PMID: 39492826 DOI: 10.3748/wjg.v30.i39.4318]
Corresponding Author of This Article
Chun-Xiang Zhang, MD, Dean, Professor, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. zhangchx999@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mo-Wei Kong, Yang Yu, Chun-Xiang Zhang, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
Peng Wang, Department of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, China
Ying Wan, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, Sichuan Province, China
Yu Gao, Department of Endocrinology, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei Province, China
Co-first authors: Mo-Wei Kong and Yang Yu.
Author contributions: Zhang CX provided crucial suggestions and guidance for the writing; Wang P, Wan Y and Gao Y reviewed and revised the manuscript; Kong MW and Yu Y wrote the manuscript. All authors read and approved the final manuscript. Designation of Kong MW and Yu Y as joint first authors are based on three main reasons. First, the research was conducted as a collaborative effort, and the designation of joint first authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the subsequent paper. This also ensures effective communication and management of post-submission matters, ultimately enhancing the quality and reliability of the paper. Second, the entire research team comprises authors with diverse expertise and skills from various fields, and the designation of joint first authors best represent this diversity. This facilitates the most comprehensive and in-depth examination of the research topic, enriching readers' understanding by offering multiple expert perspectives. Third, Kong MW and Yu Y contributed efforts of equal substance throughout the research process. Selecting these researchers as joint first authors acknowledge and respect this equal contribution, while recognizing the spirit of teamwork and collaboration of this study.
Supported byNational Natural Science Foundation of China, No. U23A20398 and No. 82030007; and Sichuan Science and Technology Program, No. 2022YFS0578.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Xiang Zhang, MD, Dean, Professor, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. zhangchx999@163.com
Received: August 5, 2024 Revised: September 8, 2024 Accepted: September 20, 2024 Published online: October 21, 2024 Processing time: 67 Days and 18.7 Hours
Abstract
This article reviews of the original research published by Wu et al in the World Journal of Gastroenterology, delving into the pivotal role of the gut microbiota in the pathogenesis of Crohn's disease (CD). Insights were gained from fecal microbiota transplantation (FMT) in mouse models, revealing the intricate interplay between the gut microbiota, mesenteric adipose tissue (MAT), and creeping fat. The study uncovered the characteristics of inflammation and fibrosis in the MAT and intestinal tissues of patients with CD; moreover, through the FMT mouse model, it observed the impact of samples from healthy patients and those with CD on symptoms. The pathogenesis of CD is complex, and its etiology remains unclear; however, it is widely believed that gut microbiota dysbiosis plays a significant role. Recently, with the development and application of next-generation sequencing technology, research on the role of fungi in the pathogenesis and chronicity of CD has deepened. This editorial serves as a supplement to the research by Wu et al who discussed advances related to the study of fungi in CD.
Core Tip: This article offers an in-depth look at the original research by Wu et al in the World Journal of Gastroenterology, focusing on the critical role of gut microbiota in Crohn's disease (CD) pathogenesis. This study utilized fecal microbiota transplantation in mouse models to shed light on the complex relationship between the gut microbiota, mesenteric adipose tissue, and creeping fat, highlighting inflammation and fibrosis in CD-affected tissues. This underscores the influence of microbiota dysbiosis in CD and complements the findings with a discussion of emerging research on the role of fungi in CD pathogenesis and chronicity, propelled by advancements in next-generation sequencing technology.
