Zhang RN, Fan JG. Lipid metabolism-related long noncoding RNAs: A potential prognostic biomarker for hepatocellular carcinoma. World J Gastroenterol 2024; 30(33): 3799-3802 [PMID: 39351428 DOI: 10.3748/wjg.v30.i33.3799]
Corresponding Author of This Article
Jian-Gao Fan, MD, PhD, Director, Professor, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 7, 2024; 30(33): 3799-3802 Published online Sep 7, 2024. doi: 10.3748/wjg.v30.i33.3799
Lipid metabolism-related long noncoding RNAs: A potential prognostic biomarker for hepatocellular carcinoma
Rui-Nan Zhang, Jian-Gao Fan
Rui-Nan Zhang, Jian-Gao Fan, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Author contributions: Fan JG designed the overall concept and outlined the manuscript; Zhang RN reviewed the literature, wrote and edited the manuscript; Both authors have read and approved the final version to be published.
Supported byNational Natural Science Foundation of China, No. 82170593, No. 81700503; and the National Key Research and Development Program of China, No. 2021YFC2700802.
Conflict-of-interest statement: All the authors have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Gao Fan, MD, PhD, Director, Professor, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn
Received: March 26, 2024 Revised: August 13, 2024 Accepted: August 16, 2024 Published online: September 7, 2024 Processing time: 159 Days and 11.4 Hours
Abstract
The incidence rates of hepatocellular carcinoma (HCC) have increased in recent decades. Despite advancements in therapy and early diagnosis improving short-term prognosis, long-term outcomes remain poor. Long noncoding RNAs (lncRNAs) and lipid metabolism play crucial roles in the development and progression of HCC. Enhanced lipid synthesis promotes HCC progression, and lncRNAs can reprogram the expression of lipogenic enzymes. Consequently, lipid metabolism-related (LMR)-lncRNAs regulate lipid anabolism, accelerating the onset and progression of HCC. This suggests that LMR-lncRNAs could serve as novel prognostic biomarkers and therapeutic targets.
Core Tip: Lipid metabolism and long noncoding RNAs (lncRNAs) are pivotal in hepatocellular carcinoma (HCC) development. While the prognosis of HCC remains poor and prognostic biomarkers are lacking, lipid metabolism-related lncRNAs may be promising candidates for prognostic biomarkers in HCC.
