Yang S, He QY, Zhao QJ, Yang HT, Yang ZY, Che WY, Li HM, Wu HC. Gastric metastasis of small cell lung carcinoma: Three case reports and review of literature. World J Gastroenterol 2024; 30(31): 3717-3725 [PMID: 39193003 DOI: 10.3748/wjg.v30.i31.3717]
Corresponding Author of This Article
Hui-Chao Wu, MD, Chief Physician, Professor, Department of Gastroenterology, The Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi 563000, Guizhou Province, China. wuhuichao985@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Shan Yang, Qing-Yun He, Qing-Jing Zhao, Han-Tao Yang, Hui-Chao Wu, Department of Gastroenterology, The Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Qing-Yun He, Department of Nephrology, Guizhou Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guiyang 550000, Guizhou Province, China
Zheng-Yi Yang, Department of Gastroenterology, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie 551700, Guizhou Province, China
Wen-Yi Che, Hua-Mei Li, Department of Gastroenterology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Co-first authors: Shan Yang and Qing-Yun He.
Author contributions: Yang S and He QY contributed to manuscript writing and editing; Yang S and He QY contributed equally to this work as co-first authors; Zhao QJ and Yang HT contributed to pictures collection; Che WY and Li HM contributed to editing pictures; Yang ZY contributed to reviewed the literature; Wu HC contributed to revising the final manuscript; Yang S and He QY worked closely together and both made equally important contributions throughout the study; Yang S contributed greatly to the writing, revision, language editing, and literature review of the manuscript; He QY also made important contributions to the production of immunohistochemistry sections, acquisition of images, and revisions to the manuscript; Thus, we appointed Yang S and He QY as co-first authors, which can reflect our team's collaborative spirit and fairness; All authors have read and approved the final manuscript.
Informed consent statement: Informed verbal consent was obtained from the patient's families for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read CARE Checklist (2016), and the manuscript was prepared and revised according to CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hui-Chao Wu, MD, Chief Physician, Professor, Department of Gastroenterology, The Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi 563000, Guizhou Province, China. wuhuichao985@163.com
Received: May 13, 2024 Revised: July 10, 2024 Accepted: July 22, 2024 Published online: August 21, 2024 Processing time: 91 Days and 20.1 Hours
Abstract
BACKGROUND
Small cell lung carcinoma (SCLC) is highly susceptible to metastasis in the early stages of the disease. However, the stomach is an uncommon site of metastasis in SCLC, and only a few cases of this type of metastasis have been reported. Therefore, SCLC gastric metastases have not been systematically characterized and are easily missed and misdiagnosed.
CASE SUMMARY
We report three cases of gastric metastasis from SCLC in this article. The first patient presented primarily with cough, hemoptysis, and epigastric fullness. The other two patients presented primarily with abdominal discomfort, epigastric distension, and pain. All patients underwent gastroscopy and imaging examinations. Meanwhile, the immunohistochemical results of the lesions in three patients were suggestive of small cell carcinoma. Finally, the three patients were diagnosed with gastric metastasis of SCLC through a comprehensive analysis. The three patients did not receive appropriate treatment and died within a short time.
CONCLUSION
Here, we focused on summarizing the characteristics of gastric metastasis of SCLC to enhance clinicians' understanding of this disease.
Core Tip: Due to the rarity of small cell lung carcinoma (SCLC) gastric metastasis, few cases have been reported internationally, and clinicians are not sufficiently aware of the clinical features of this group of diseases. In this article, we report three cases of SCLC gastric metastasis to summarize the characteristics of this type of disease and improve the understanding of the diagnosis and treatment of SCLC gastric metastasis.
