Yuan JH, Luo S, Zhang DG, Wang LS. Early detection of multiple endocrine neoplasia type 1: A case report. World J Gastroenterol 2024; 30(26): 3247-3252 [DOI: 10.3748/wjg.v30.i26.3247]
Corresponding Author of This Article
Ding-Guo Zhang, MD, Associate Professor, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), No. 1017 Dongmen North Road, Luohu District, Shenzhen 518020, Guangdong Province, China. zdg8012@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 14, 2024; 30(26): 3247-3252 Published online Jul 14, 2024. doi: 10.3748/wjg.v30.i26.3247
Early detection of multiple endocrine neoplasia type 1: A case report
Jie-Hao Yuan, Su Luo, Ding-Guo Zhang, Li-Sheng Wang
Jie-Hao Yuan, Su Luo, Ding-Guo Zhang, Li-Sheng Wang, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen 518020, Guangdong Province, China
Co-corresponding authors: Ding-Guo Zhang and Li-Sheng Wang.
Author contributions: Yuan JH collected the data and drafted the manuscript; Luo S performed the electronic gastroscopy and ultrasound gastroscopy; Zhang DG and Wang LS diagnosed and clarified the final treatment plan for the patient and revised the manuscript, they are the co-corresponding authors of this manuscript; and all the authors read and approved the final manuscript.
Supported bySanming Project of Medicine in Shenzhen, No. SZSM202211029.
Informed consent statement: Written, informed consent was obtained from the patient for publication of the patient’s medical case and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ding-Guo Zhang, MD, Associate Professor, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), No. 1017 Dongmen North Road, Luohu District, Shenzhen 518020, Guangdong Province, China. zdg8012@sina.com
Received: April 26, 2024 Revised: May 28, 2024 Accepted: June 20, 2024 Published online: July 14, 2024 Processing time: 73 Days and 23.3 Hours
Abstract
BACKGROUND
Multiple endocrine neoplasias (MENs) are a group of hereditary diseases involving multiple endocrine glands, and their prevalence is low. MEN type 1 (MEN1) has diverse clinical manifestations, mainly involving the parathyroid glands, gastrointestinal tract, pancreas and pituitary gland, making it easy to miss the clinical diagnosis.
CASE SUMMARY
We present the case of a patient in whom MEN1 was detected early. A middle-aged male with recurrent abdominal pain and diarrhea was admitted to the hospital. Blood tests at admission revealed hypercalcemia and hypophosphatemia, and emission computed tomography of the parathyroid glands revealed a hyperfunctioning parathyroid lesion. Gastroscopy findings suggested a duodenal bulge and ulceration. Ultrasound endoscopy revealed a hypoechoic lesion in the duodenal bulb. Further blood tests revealed elevated levels of serum gastrin. Surgery was performed, and pathological analysis of the surgical specimens revealed a parathyroid adenoma after parathyroidectomy and a neuroendocrine tumor after duodenal bulbectomy. The time from onset to the definitive diagnosis of MEN1 was only approximately 1 year.
CONCLUSION
For patients who present with gastrointestinal symptoms accompanied by hypercalcemia and hypophosphatemia, clinicians need to be alert to the possibility of MEN1.
Core Tip: Multiple endocrine neoplasia type 1 (MEN1) mainly affects the parathyroid glands, gastrointestinal tract, pancreas and pituitary gland and manifests as parathyroid adenomas, gastrinomas, insulinomas and pituitary tumors. As a rare disease, MEN1 is easily missed in clinical practice. We analyzed a case of MEN in a patient who had gastrointestinal symptoms as the main manifestation, and this report provides a reference for MEN1 clinical diagnosis and treatment.
